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10.1038/nrmicro.2016.17

http://scihub22266oqcxt.onion/10.1038/nrmicro.2016.17
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C5243131!5243131!26972811
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suck abstract from ncbi


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pmid26972811      Nat+Rev+Microbiol 2016 ; 14 (5): 273-87
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  • The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism #MMPMID26972811
  • Spanogiannopoulos P; Bess EN; Carmody RN; Turnbaugh PJ
  • Nat Rev Microbiol 2016[Apr]; 14 (5): 273-87 PMID26972811show ga
  • Although the significance of human genetic polymorphisms in therapeutic outcomes is well established, the importance of our ?second genome? (the microbiome) has been largely overlooked. In this Review, we highlight recent studies that shed light on the mechanisms linking the human gut microbiome to the efficacy and toxicity of xenobiotics, including drugs, dietary compounds and environmental toxins. Continued progress in this area could enable more precise tools for predicting patient responses and the development of a next generation of therapeutics based on or targeted at the gut microbiome. Indeed, the admirable goal of precision medicine may require us to first understand the microbial pharmacists within.
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