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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nat+Rev+Microbiol 2016 ; 14 (5): 273-87 Nephropedia Template TP
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The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism #MMPMID26972811
Nat Rev Microbiol 2016[Apr]; 14 (5): 273-87 PMID26972811show ga
Although the significance of human genetic polymorphisms in therapeutic outcomes is well established, the importance of our ?second genome? (the microbiome) has been largely overlooked. In this Review, we highlight recent studies that shed light on the mechanisms linking the human gut microbiome to the efficacy and toxicity of xenobiotics, including drugs, dietary compounds and environmental toxins. Continued progress in this area could enable more precise tools for predicting patient responses and the development of a next generation of therapeutics based on or targeted at the gut microbiome. Indeed, the admirable goal of precision medicine may require us to first understand the microbial pharmacists within.