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10.1136/bmj.i6770 http://scihub22266oqcxt.onion/10.1136/bmj.i6770 C5241252!5241252 !28096109     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28096109 &cmd=llinks): Failed to open stream: HTTP request failed! 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Financial ties of principal investigators and randomized controlled trial outcomes: cross sectional study |pdf=|usr=}}{{28096109 }} gab.com Text Financial ties of principal investigators and randomized controlled trial outcomes: cross sectional study JO: BMJ http://www.kidney.de/pget.php?&tw=1&pmid=28096109 #FOAvip OBJECTIVE:  To examine the association between the presence of individual principal investigators' financial ties to the manufacturer of the study drug and the trial's outcomes after accounting for source of research funding. DESIGN:  Cross sectional study of randomized controlled trials (RCTs). SETTING:  Studies published in "core clinical" journals, as identified by Medline, between 1 January 2013 and 31 December 2013. PARTICIPANTS:  Random sample of RCTs focused on drug efficacy. MAIN OUTCOME MEASURE:  Association between financial ties of principal investigators and study outcome. RESULTS:  A total of 190 papers describing 195 studies met inclusion criteria. Financial ties between principal investigators and the pharmaceutical industry were present in 132 (67.7%) studies. Of 397 principal investigators, 231 (58%) had financial ties and 166 (42%) did not. Of all principal investigators, 156 (39%) reported advisor/consultancy payments, 81 (20%) reported speakers' fees, 81 (20%) reported unspecified financial ties, 52 (13%) reported honorariums, 52 (13%) reported employee relationships, 52 (13%) reported travel fees, 41 (10%) reported stock ownership, and 20 (5%) reported having a patent related to the study drug. The prevalence of financial ties of principal investigators was 76% (103/136) among positive studies and 49% (29/59) among negative studies. In unadjusted analyses, the presence of a financial tie was associated with a positive study outcome (odds ratio 3.23, 95% confidence interval 1.7 to 6.1). In the primary multivariate analysis, a financial tie was significantly associated with positive RCT outcome after adjustment for the study funding source (odds ratio 3.57 (1.7 to 7.7). The secondary analysis controlled for additional RCT characteristics such as study phase, sample size, country of first authors, specialty, trial registration, study design, type of analysis, comparator, and outcome measure. These characteristics did not appreciably affect the relation between financial ties and study outcomes (odds ratio 3.37, 1.4 to 7.9). CONCLUSIONS:  Financial ties of principal investigators were independently associated with positive clinical trial results. These findings may be suggestive of bias in the evidence base. Twit Text FOAVip Financial ties of principal investigators and randomized controlled trial outcomes: cross sectional study ????BMJ http://www.kidney.de/pget.php?&tw=1&pmid=28096109 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28096109 #FOAvip English Wikipedia <ref>{{Cite pmid|28096109 }}</ref> Financial ties of principal investigators and randomized controlled trial outcomes: cross sectional study #MMPMID28096109 Ahn R ; Woodbridge A ; Abraham A ; Saba S ; Korenstein D ; Madden E ; Boscardin WJ ; Keyhani S BMJ 2017[Jan]; 356 (ä): i6770 PMID28096109 show ga OBJECTIVE:  To examine the association between the presence of individual principal investigators' financial ties to the manufacturer of the study drug and the trial's outcomes after accounting for source of research funding. DESIGN:  Cross sectional study of randomized controlled trials (RCTs). SETTING:  Studies published in "core clinical" journals, as identified by Medline, between 1 January 2013 and 31 December 2013. PARTICIPANTS:  Random sample of RCTs focused on drug efficacy. MAIN OUTCOME MEASURE:  Association between financial ties of principal investigators and study outcome. RESULTS:  A total of 190 papers describing 195 studies met inclusion criteria. Financial ties between principal investigators and the pharmaceutical industry were present in 132 (67.7%) studies. Of 397 principal investigators, 231 (58%) had financial ties and 166 (42%) did not. Of all principal investigators, 156 (39%) reported advisor/consultancy payments, 81 (20%) reported speakers' fees, 81 (20%) reported unspecified financial ties, 52 (13%) reported honorariums, 52 (13%) reported employee relationships, 52 (13%) reported travel fees, 41 (10%) reported stock ownership, and 20 (5%) reported having a patent related to the study drug. The prevalence of financial ties of principal investigators was 76% (103/136) among positive studies and 49% (29/59) among negative studies. In unadjusted analyses, the presence of a financial tie was associated with a positive study outcome (odds ratio 3.23, 95% confidence interval 1.7 to 6.1). In the primary multivariate analysis, a financial tie was significantly associated with positive RCT outcome after adjustment for the study funding source (odds ratio 3.57 (1.7 to 7.7). The secondary analysis controlled for additional RCT characteristics such as study phase, sample size, country of first authors, specialty, trial registration, study design, type of analysis, comparator, and outcome measure. These characteristics did not appreciably affect the relation between financial ties and study outcomes (odds ratio 3.37, 1.4 to 7.9). CONCLUSIONS:  Financial ties of principal investigators were independently associated with positive clinical trial results. These findings may be suggestive of bias in the evidence base. |*Conflict of Interest/economics [MESH] |Cross-Sectional Studies [MESH] |Drug Industry/*economics [MESH] |Ethics, Research [MESH] |Humans [MESH] |Outcome Assessment, Health Care [MESH] |Randomized Controlled Trials as Topic/*economics [MESH] |Research Personnel/*economics [MESH]Financial ties of principal investigators and randomized controlled tr(epmc).pdf DeepDyve Pubget Overpricing