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10.1016/j.tig.2016.09.005 http://scihub22266oqcxt.onion/10.1016/j.tig.2016.09.005 C5235059!5235059!27692431     free     free     free       Trends+Genet 2016 ; 32 (11): 751-61 Nephropedia Template TP {{tp|p=27692431|t=2016. The chromatin landscape of cellular senescence |pdf=|usr=}}{{27692431}} gab.com Text The chromatin landscape of cellular senescence JO: Trends Genet http://www.kidney.de/pget.php?&tw=1&pmid=27692431 #FOAvip Cellular senescence, an irreversible growth arrest triggered by a variety of stressors, plays important roles in normal physiology and tumor suppression, but accumulation of senescent cells with age contributes to the functional decline of tissues. Senescent cells undergo dramatic alterations to their chromatin landscape that affect genome accessibility and their transcriptional program. These include the loss of DNA-nuclear lamina interactions, the distension of centromeres, and changes in chromatin composition that can lead to the activation of retrotransposons. Here we discuss these findings, as well as recent advances in microscopy and genomics that have revealed the importance of the higher-order spatial organization of the genome in defining and maintaining the senescent state. Twit Text FOAVip The chromatin landscape of cellular senescence ????Trends Genet http://www.kidney.de/pget.php?&tw=1&pmid=27692431 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27692431 #FOAvip English Wikipedia <ref>{{Cite pmid|27692431}}</ref> The chromatin landscape of cellular senescence #MMPMID27692431 Criscione SW; Teo YV; Neretti N Trends Genet 2016[Nov]; 32 (11): 751-61 PMID27692431show ga Cellular senescence, an irreversible growth arrest triggered by a variety of stressors, plays important roles in normal physiology and tumor suppression, but accumulation of senescent cells with age contributes to the functional decline of tissues. Senescent cells undergo dramatic alterations to their chromatin landscape that affect genome accessibility and their transcriptional program. These include the loss of DNA-nuclear lamina interactions, the distension of centromeres, and changes in chromatin composition that can lead to the activation of retrotransposons. Here we discuss these findings, as well as recent advances in microscopy and genomics that have revealed the importance of the higher-order spatial organization of the genome in defining and maintaining the senescent state. äThe chromatin landscape of cellular senescence (epmc).pdf DeepDyve Pubget Overpricing