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10.1002/eji.201545955

http://scihub22266oqcxt.onion/10.1002/eji.201545955
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C5227655!5227655!27151577
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suck abstract from ncbi


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pmid27151577      Eur+J+Immunol 2016 ; 46 (6): 1326-34
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  • Key roles of autophagy in the regulation of T-cell function #MMPMID27151577
  • Botbol Y; Guerrero-Ros I; Macian F
  • Eur J Immunol 2016[Jun]; 46 (6): 1326-34 PMID27151577show ga
  • In the past 10 years, autophagy has emerged as a crucial regulator of T-cell homeostasis, activation and differentiation. Through the ability to adjust the cell?s proteome in response to different stimuli, different forms of autophagy have been shown to control T-cell homeostasis and survival. Autophagic processes can also determine the magnitude of the T-cell response to TCR engagement, by regulating the cellular levels of specific signaling intermediates and modulating the metabolic output in activated T-cells. In this review we will examine the mechanisms that control autophagy activity in T-cells, such as ROS signaling and signaling through common gamma-chain cytokine receptors, and the different aspect of T-cell biology, including, T-cell survival, effector cell function and generation of memory, which can be regulated by autophagy.
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