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10.1016/j.ajpath.2016.07.017

http://scihub22266oqcxt.onion/10.1016/j.ajpath.2016.07.017
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C5225285!5225285!27643530
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suck abstract from ncbi

pmid27643530      Am+J+Pathol 2016 ; 186 (11): 2783-97
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  • Electrical Stimulation as a Means for Improving Vision #MMPMID27643530
  • Sehic A; Guo S; Cho KS; Corraya RM; Chen DF; Utheim TP
  • Am J Pathol 2016[Nov]; 186 (11): 2783-97 PMID27643530show ga
  • Evolving research has provided evidence that noninvasive electrical stimulation (ES) of the eye may be a promising therapy for either preserving or restoring vision in several retinal and optic nerve diseases. In this review, we focus on minimally invasive strategies for the delivery of ES and accordingly summarize the current literature on transcorneal, transorbital, and transpalpebral ES in both animal experiments and clinical studies. Various mechanisms are believed to underlie the effects of ES, including increased production of neurotrophic agents, improved chorioretinal blood circulation, and inhibition of proinflammatory cytokines. Different animal models have demonstrated favorable effects of ES on both the retina and the optic nerve. Promising effects of ES have also been demonstrated in clinical studies; however, all current studies have a lack of randomization and/or a control group (sham). There is thus a pressing need for a deeper understanding of the underlying mechanisms that govern clinical success and optimization of stimulation parameters in animal studies. In addition, such research should be followed by large, prospective, clinical studies to explore the full potential of ES. Through this review, we aim to provide insight to guide future research on ES as a potential therapy for improving vision.
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