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10.1083/jcb.201609094 http://scihub22266oqcxt.onion/10.1083/jcb.201609094 C5223609!5223609 !28031421     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28031421 &cmd=llinks): Failed to open stream: HTTP request failed! 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The palmitoyltransferase Approximated promotes growth via the Hippo pathway by palmitoylation of Fat |pdf=|usr=}}{{28031421 }} gab.com Text The palmitoyltransferase Approximated promotes growth via the Hippo pathway by palmitoylation of Fat JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28031421 #FOAvip The large protocadherin Fat functions to promote Hippo pathway activity in restricting tissue growth. Loss of Fat leads to accumulation of the atypical myosin Dachs at the apical junctional region, which in turn promotes growth by inhibiting Warts. We previously identified Approximated (App), a DHHC domain palmitoyltransferase, as a negative regulator of Fat signaling in growth control. We show here that App promotes growth by palmitoylating the intracellular domain of Fat, and that palmitoylation negatively regulates Fat function. Independently, App also recruits Dachs to the apical junctional region through protein-protein association, thereby stimulating Dachs's activity in promoting growth. Further, we show that palmitoylation by App functions antagonistically to phosphorylation by Discs-overgrown, which activates Fat. Together, these findings suggest a model in which App promotes Dachs activity by simultaneously repressing Fat via posttranslational modification and recruiting Dachs to the apical junctional region, thereby promoting tissue growth. Twit Text FOAVip The palmitoyltransferase Approximated promotes growth via the Hippo pathway by palmitoylation of Fat ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28031421 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28031421 #FOAvip English Wikipedia <ref>{{Cite pmid|28031421 }}</ref> The palmitoyltransferase Approximated promotes growth via the Hippo pathway by palmitoylation of Fat #MMPMID28031421 Matakatsu H ; Blair SS ; Fehon RG J Cell Biol 2017[Jan]; 216 (1 ): 265-277 PMID28031421 show ga The large protocadherin Fat functions to promote Hippo pathway activity in restricting tissue growth. Loss of Fat leads to accumulation of the atypical myosin Dachs at the apical junctional region, which in turn promotes growth by inhibiting Warts. We previously identified Approximated (App), a DHHC domain palmitoyltransferase, as a negative regulator of Fat signaling in growth control. We show here that App promotes growth by palmitoylating the intracellular domain of Fat, and that palmitoylation negatively regulates Fat function. Independently, App also recruits Dachs to the apical junctional region through protein-protein association, thereby stimulating Dachs's activity in promoting growth. Further, we show that palmitoylation by App functions antagonistically to phosphorylation by Discs-overgrown, which activates Fat. Together, these findings suggest a model in which App promotes Dachs activity by simultaneously repressing Fat via posttranslational modification and recruiting Dachs to the apical junctional region, thereby promoting tissue growth. |Acyltransferases/genetics/*metabolism [MESH] |Animals [MESH] |Casein Kinase 1 epsilon/genetics/metabolism [MESH] |Cell Adhesion Molecules/genetics/*metabolism [MESH] |Cell Line [MESH] |Drosophila Proteins/genetics/*metabolism [MESH] |Drosophila melanogaster/*enzymology/genetics/growth & development [MESH] |Genotype [MESH] |Intracellular Signaling Peptides and Proteins/genetics/*metabolism [MESH] |Lipoylation [MESH] |Myosins/genetics/metabolism [MESH] |Phenotype [MESH] |Phosphorylation [MESH] |Protein Binding [MESH] |Protein Domains [MESH] |Protein Processing, Post-Translational [MESH] |Protein Serine-Threonine Kinases/genetics/*metabolism [MESH]The palmitoyltransferase Approximated promotes growth via the Hippo pa(epmc).pdf DeepDyve Pubget Overpricing