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10.1083/jcb.201607110

http://scihub22266oqcxt.onion/10.1083/jcb.201607110
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C5223607!5223607!27986797
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suck abstract from ncbi


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pmid27986797      J+Cell+Biol 2017 ; 216 (1): 149-65
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  • Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis #MMPMID27986797
  • Chung HK; Ryu D; Kim KS; Chang JY; Kim YK; Yi HS; Kang SG; Choi MJ; Lee SE; Jung SB; Ryu MJ; Kim SJ; Kweon GR; Kim H; Hwang JH; Lee CH; Lee SJ; Wall CE; Downes M; Evans RM; Auwerx J; Shong M
  • J Cell Biol 2017[Jan]; 216 (1): 149-65 PMID27986797show ga
  • Chung et al. show that the myomitokine GDF15 can act to modulate oxidative and lipolytic function in a non?cell-autonomous manner, thereby regulating systemic energy homeostasis in skeletal muscle-specific Crif1-deficient mice. This pathway may be a potential therapeutic target for preventing the onset of obesity and insulin resistance.
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