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Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Cell+Biol 2017 ; 216 (1): 181-97 Nephropedia Template TP
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Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO #MMPMID28007915
Rafiq NBM; Lieu ZZ; Jiang T; Yu Ch; Matsudaira P; Jones GE; Bershadsky AD
J Cell Biol 2017[Jan]; 216 (1): 181-97 PMID28007915show ga
Rafiq et al. demonstrate that the small G protein ARF1 and its activator, cytohesin 2 (ARNO), are required for podosome formation in macrophage-like cells and fibroblasts. Inhibition of ARNO-ARF1 signaling results in increased RhoA activity and disassembly of podosomes in a myosin-IIA?dependent fashion. In fibroblasts that normally do not form podosomes, constitutively active ARF1 induces actin-rich puncta associated with sites of matrix degradation, putative precursors of podosomes.