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10.1083/jcb.201605104

http://scihub22266oqcxt.onion/10.1083/jcb.201605104
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C5223603!5223603!28007915
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suck abstract from ncbi


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pmid28007915      J+Cell+Biol 2017 ; 216 (1): 181-97
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  • Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO #MMPMID28007915
  • Rafiq NBM; Lieu ZZ; Jiang T; Yu Ch; Matsudaira P; Jones GE; Bershadsky AD
  • J Cell Biol 2017[Jan]; 216 (1): 181-97 PMID28007915show ga
  • Rafiq et al. demonstrate that the small G protein ARF1 and its activator, cytohesin 2 (ARNO), are required for podosome formation in macrophage-like cells and fibroblasts. Inhibition of ARNO-ARF1 signaling results in increased RhoA activity and disassembly of podosomes in a myosin-IIA?dependent fashion. In fibroblasts that normally do not form podosomes, constitutively active ARF1 induces actin-rich puncta associated with sites of matrix degradation, putative precursors of podosomes.
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