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10.1016/j.ajhg.2016.11.007 http://scihub22266oqcxt.onion/10.1016/j.ajhg.2016.11.007 C5223028!5223028 !27989323     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27989323 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Hum+Genet 2017 ; 100 (1 ): 40-50 Nephropedia Template TP {{tp|p=27989323 |t=2017. Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors |pdf=|usr=}}{{27989323 }} gab.com Text Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors JO: Am J Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=27989323 #FOAvip Circulating cytokines and growth factors are regulators of inflammation and have been implicated in autoimmune and metabolic diseases. In this genome-wide association study (GWAS) of up to 8,293 Finns we identified 27 genome-widely significant loci (p < 1.2 × 10(-9)) for one or more cytokines. Fifteen of the associated variants had expression quantitative trait loci in whole blood. We provide genetic instruments to clarify the causal roles of cytokine signaling and upstream inflammation in immune-related and other chronic diseases. We further link inflammatory markers with variants previously associated with autoimmune diseases such as Crohn disease, multiple sclerosis, and ulcerative colitis and hereby elucidate the molecular mechanisms underpinning these diseases and suggest potential drug targets. Twit Text FOAVip Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors ????Am J Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=27989323 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27989323 #FOAvip English Wikipedia <ref>{{Cite pmid|27989323 }}</ref> Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors #MMPMID27989323 Ahola-Olli AV ; Würtz P ; Havulinna AS ; Aalto K ; Pitkänen N ; Lehtimäki T ; Kähönen M ; Lyytikäinen LP ; Raitoharju E ; Seppälä I ; Sarin AP ; Ripatti S ; Palotie A ; Perola M ; Viikari JS ; Jalkanen S ; Maksimow M ; Salomaa V ; Salmi M ; Kettunen J ; Raitakari OT Am J Hum Genet 2017[Jan]; 100 (1 ): 40-50 PMID27989323 show ga Circulating cytokines and growth factors are regulators of inflammation and have been implicated in autoimmune and metabolic diseases. In this genome-wide association study (GWAS) of up to 8,293 Finns we identified 27 genome-widely significant loci (p < 1.2 × 10(-9)) for one or more cytokines. Fifteen of the associated variants had expression quantitative trait loci in whole blood. We provide genetic instruments to clarify the causal roles of cytokine signaling and upstream inflammation in immune-related and other chronic diseases. We further link inflammatory markers with variants previously associated with autoimmune diseases such as Crohn disease, multiple sclerosis, and ulcerative colitis and hereby elucidate the molecular mechanisms underpinning these diseases and suggest potential drug targets. |*Genome-Wide Association Study [MESH] |Autoimmune Diseases/genetics [MESH] |Colitis, Ulcerative/genetics [MESH] |Crohn Disease/genetics [MESH] |Cytokines/*blood [MESH] |Female [MESH] |Humans [MESH] |Inflammation/genetics [MESH] |Intercellular Signaling Peptides and Proteins/*blood [MESH] |Male [MESH] |Multiple Sclerosis/genetics [MESH]Genome-wide Association Study Identifies 27 Loci Influencing Concentra(epmc).pdf DeepDyve Pubget Overpricing