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10.1002/jcp.25263

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C5222602!5222602!26588184
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suck abstract from ncbi


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pmid26588184      J+Cell+Physiol 2016 ; 231 (7): 1621-7
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  • STRETCHING IMPACTS INFLAMMATION RESOLUTION IN CONNECTIVE TISSUE #MMPMID26588184
  • Berrueta L; Muskaj I; Olenich S; Butler T; Badger GJ; Colas RA; Spite M; Serhan CN; Langevin HM
  • J Cell Physiol 2016[Jul]; 231 (7): 1621-7 PMID26588184show ga
  • Acute inflammation is accompanied from its outset by the release of specialized pro-resolving mediators (SPMs), including resolvins, that orchestrate the resolution of local inflammation. We showed earlier that, in rats with subcutaneous inflammation of the back induced by carrageenan, stretching for 10 minutes twice daily reduced inflammation and improved pain, two weeks after carrageenan injection. In this study, we hypothesized that stretching of connective tissue activates local pro-resolving mechanisms within the tissue in the acute phase of inflammation. In rats injected with carrageenan and randomized to stretch vs. no stretch for 48 hours, stretching reduced inflammatory lesion thickness and neutrophil count, and increased resolvin (RvD1) concentrations within lesions. Furthermore, subcutaneous resolvin injection mimicked the effect of stretching. In ex vivo experiments, stretching of connective tissue reduced the migration of neutrophils and increased tissue RvD1 concentration. These results demonstrate a direct mechanical impact of stretching on inflammation-regulation mechanisms within connective tissue.
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