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10.1091/mbc.E16-07-0557

http://scihub22266oqcxt.onion/10.1091/mbc.E16-07-0557
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C5221518!5221518!27852897
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suck abstract from ncbi


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pmid27852897      Mol+Biol+Cell 2017 ; 28 (1): 41-53
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  • Reconstituting regulation of the canonical Wnt pathway by engineering a minimal ?-catenin destruction machine #MMPMID27852897
  • Pronobis MI; Deuitch N; Posham V; Mimori-Kiyosue Y; Peifer M
  • Mol Biol Cell 2017[Jan]; 28 (1): 41-53 PMID27852897show ga
  • APC and Axin are key negative regulators of Wnt signaling in development and oncogenesis. They form a multiprotein complex targeting the key Wnt effector ?-catenin for destruction. Essential components of APC and Axin required for their cooperative function are identified, and the data are used to design a minimal ?-catenin?destruction machine.
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