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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Biophys+Physicobiol 2016 ; 13 (ä): 251-62 Nephropedia Template TP
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Statistical mechanics of protein structural transitions: Insights from the island model #MMPMID28409078
Kobayashi Y
Biophys Physicobiol 2016[]; 13 (ä): 251-62 PMID28409078show ga
The so-called island model of protein structural transition holds that hydrophobic interactions are the key to both the folding and function of proteins. Herein, the genesis and statistical mechanical basis of the island model of transitions are reviewed, by presenting the results of simulations of such transitions. Elucidating the physicochemical mechanism of protein structural formation is the foundation for understanding the hierarchical structure of life at the microscopic level. Based on the results obtained to date using the island model, remaining problems and future work in the field of protein structures are discussed, referencing Professor Saitô?s views on the hierarchic structure of science.