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10.7554/eLife.20914 http://scihub22266oqcxt.onion/10.7554/eLife.20914 C5218537!5218537!27991852     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       eLife 2016 ; 5 (ä): ä Nephropedia Template TP {{tp|p=27991852|t=2016. Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival |pdf=|usr=}}{{27991852}} gab.com Text Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=27991852 #FOAvip Mg2+ regulates many physiological processes and signalling pathways. However, little is known about the mechanisms underlying the organismal balance of Mg2+. Capitalizing on a set of newly generated mouse models, we provide an integrated mechanistic model of the regulation of organismal Mg2+ balance during prenatal development and in adult mice by the ion channel TRPM6. We show that TRPM6 activity in the placenta and yolk sac is essential for embryonic development. In adult mice, TRPM6 is required in the intestine to maintain organismal Mg2+ balance, but is dispensable in the kidney. Trpm6 inactivation in adult mice leads to a shortened lifespan, growth deficit and metabolic alterations indicative of impaired energy balance. Dietary Mg2+ supplementation not only rescues all phenotypes displayed by Trpm6-deficient adult mice, but also may extend the lifespan of wildtype mice. Hence, maintenance of organismal Mg2+ balance by TRPM6 is crucial for prenatal development and survival to adulthood.DOI:http://dx.doi.org/10.7554/eLife.20914.001 Twit Text FOAVip Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=27991852 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27991852 #FOAvip English Wikipedia <ref>{{Cite pmid|27991852}}</ref> Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival #MMPMID27991852 Chubanov V; Ferioli S; Wisnowsky A; Simmons DG; Leitzinger C; Einer C; Jonas W; Shymkiv Y; Bartsch H; Braun A; Akdogan B; Mittermeier L; Sytik L; Torben F; Jurinovic V; van der Vorst EP; Weber C; Yildirim ÖA; Sotlar K; Schürmann A; Zierler S; Zischka H; Ryazanov AG; Gudermann T eLife 2016[]; 5 (ä): ä PMID27991852show ga Mg2+ regulates many physiological processes and signalling pathways. However, little is known about the mechanisms underlying the organismal balance of Mg2+. Capitalizing on a set of newly generated mouse models, we provide an integrated mechanistic model of the regulation of organismal Mg2+ balance during prenatal development and in adult mice by the ion channel TRPM6. We show that TRPM6 activity in the placenta and yolk sac is essential for embryonic development. In adult mice, TRPM6 is required in the intestine to maintain organismal Mg2+ balance, but is dispensable in the kidney. Trpm6 inactivation in adult mice leads to a shortened lifespan, growth deficit and metabolic alterations indicative of impaired energy balance. Dietary Mg2+ supplementation not only rescues all phenotypes displayed by Trpm6-deficient adult mice, but also may extend the lifespan of wildtype mice. Hence, maintenance of organismal Mg2+ balance by TRPM6 is crucial for prenatal development and survival to adulthood.DOI:http://dx.doi.org/10.7554/eLife.20914.001 äEpithelial magnesium transport by TRPM6 is essential for prenatal deve(epmc).pdf DeepDyve Pubget Overpricing