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10.1080/2162402X.2016.1238543 http://scihub22266oqcxt.onion/10.1080/2162402X.2016.1238543 C5215235!5215235!28123874     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncoimmunology 2016 ; 5 (12): ä Nephropedia Template TP {{tp|p=28123874|t=2016. Deficiency of the adaptor protein SLy1 results in a natural killer cell ribosomopathy affecting tumor clearance |pdf=|usr=}}{{28123874}} gab.com Text Deficiency of the adaptor protein SLy1 results in a natural killer cell ribosomopathy affecting tumor clearance JO: Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=28123874 #FOAvip Individuals with robust natural killer (NK) cell function incur lower rates of malignancies. To expand our understanding of genetic factors contributing to this phenomenon, we analyzed NK cells from cancer resistant and susceptible strains of mice. We identified a correlation between NK levels of the X-chromosome-located adaptor protein SLy1 and immunologic susceptibility to cancer. Unlike the case for T or B lymphocytes, where SLy1 shuttles between the cytoplasm and nucleus to facilitate signal transduction, in NK cells SLy1 functions as a ribosomal protein and is located solely in the cytoplasm. In its absence, ribosomal instability results in p53-mediated NK cell senescence and decreased clearance of malignancies. NK defects are reversible under inflammatory conditions and viral clearance is not impacted by SLy1 deficiency. Our work defines a previously unappreciated X-linked ribosomopathy that results in a specific and subtle NK cell dysfunction leading to immunologic susceptibility to cancer. Twit Text FOAVip Deficiency of the adaptor protein SLy1 results in a natural killer cell ribosomopathy affecting tumor clearance ????Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=28123874 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28123874 #FOAvip English Wikipedia <ref>{{Cite pmid|28123874}}</ref> Deficiency of the adaptor protein SLy1 results in a natural killer cell ribosomopathy affecting tumor clearance #MMPMID28123874 Arefanian S; Schäll D; Chang S; Ghasemi R; Higashikubo R; Zheleznyak A; Guo Y; Yu J; Asgharian H; Li W; Gelman AE; Kreisel D; French AR; Zaher H; Plougastel-Douglas B; Maggi L; Yokoyama W; Beer-Hammer S; Krupnick AS Oncoimmunology 2016[]; 5 (12): ä PMID28123874show ga Individuals with robust natural killer (NK) cell function incur lower rates of malignancies. To expand our understanding of genetic factors contributing to this phenomenon, we analyzed NK cells from cancer resistant and susceptible strains of mice. We identified a correlation between NK levels of the X-chromosome-located adaptor protein SLy1 and immunologic susceptibility to cancer. Unlike the case for T or B lymphocytes, where SLy1 shuttles between the cytoplasm and nucleus to facilitate signal transduction, in NK cells SLy1 functions as a ribosomal protein and is located solely in the cytoplasm. In its absence, ribosomal instability results in p53-mediated NK cell senescence and decreased clearance of malignancies. NK defects are reversible under inflammatory conditions and viral clearance is not impacted by SLy1 deficiency. Our work defines a previously unappreciated X-linked ribosomopathy that results in a specific and subtle NK cell dysfunction leading to immunologic susceptibility to cancer. äDeficiency of the adaptor protein SLy1 results in a natural killer cel(epmc).pdf DeepDyve Pubget Overpricing