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2016 ; 5
(12
): e1235106
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Intratumoral natural killer cells show reduced effector and cytolytic properties
and control the differentiation of effector Th1 cells
#MMPMID28151533
Paul S
; Kulkarni N
; Shilpi
; Lal G
Oncoimmunology
2016[]; 5
(12
): e1235106
PMID28151533
show ga
Natural killer (NK) cells are known to have effector and cytolytic properties to
kill virus infected or tumor cells spontaneously. Due to these properties, NK
cells have been used as an adoptive cellular therapy to control tumor growth in
various clinical trials but have shown limited clinical benefits. This indicates
that our knowledge about phenotypic and functional differences in NK cells within
the tumor microenvironment and secondary lymphoid tissues is incomplete. In this
work, we report that B16F10 cell-induced melanoma recruits the CD11b(+)CD27(+)
subset of NK cells at a very early stage during tumor progression. These
intratumoral NK cells showed increased expression of CD69, reduced inhibitory
receptor KLRG1, and decreased proliferative ability. As compared to splenic NK
cells, intratumoral NK cells showed decreased expression of activating receptors
NKG2D, Ly49D and Ly49H; increased inhibitory receptors, NKG2A and Ly49A;
decreased cytokines IFN? and GM-CSF; decreased cytokine receptors IL-21R, IL-6R?,
and CD122 expression. Depletion of NK cells led to decrease peripheral as well as
intratumoral effector CD4(+)T-bet(+) cells (Th1), and increased tumor growth.
Furthermore, purified NK cells showed increased differentiation of Th1 cells in
an IFN?-dependent manner. Anti-NKG2D in the culture promoted differentiation of
effector Th1 cells. Collectively, these observations suggest that intratumoral NK
cells possess several inhibitory functions that can be partly reversed by
signaling through the NKG2D receptor or by cytokine stimulation, which then leads
to increased differentiation of effector Th1 cells.
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