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2013 ; 27
(4
): 501-13
Nephropedia Template TP
gab.com Text
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English Wikipedia
Apathy in Parkinson s disease: diagnosis, neuropsychological correlates,
pathophysiology and treatment
#MMPMID23242365
Santangelo G
; Trojano L
; Barone P
; Errico D
; Grossi D
; Vitale C
Behav Neurol
2013[Jan]; 27
(4
): 501-13
PMID23242365
show ga
Apathy has been defined as lack of motivation. It has been traditionally
considered as a symptom of psychiatric disorders, such as major depression and
schizophrenia, but more recently it has been recognized as a specific
neuropsychiatric syndrome associated with neurodegenerative such as Parkinson's
disease (PD). As a consequence the reported prevalence of apathy in PD ranges
from 13.9% to 70%; the mean prevalence is 35%. Prevalence of "pure apathy" (i.e.,
of apathy without comorbid depression and dementia) seems to be substantially
lower, from 3 to 47.9%. High levels of apathy in PD are associated with decreased
daily function, specific cognitive deficits and increased stress for families.
Although neuroimaging studies do not provide a unique anatomic pattern, several
data suggest that the ventromedial prefrontal cortex and the basal ganglia
connected through frontal-subcortical circuits, are particularly involved in the
genesis of apathy. At present, there are no approved medications for the
treatment of apathy in and no proof of efficacy exists for any drug in current
use. Further studies and innovative pharmacologic approaches are thus needed to
ameliorate our understanding and treatment of apathy in PD.