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10.1038/nm.4200 http://scihub22266oqcxt.onion/10.1038/nm.4200 C5209798!5209798 !27775706     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27775706 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Med 2016 ; 22 (12 ): 1402-1410 Nephropedia Template TP {{tp|p=27775706 |t=2016. Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses |pdf=|usr=}}{{27775706 }} gab.com Text Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=27775706 #FOAvip Checkpoint blockade with antibodies specific for cytotoxic T lymphocyte-associated protein (CTLA)-4 or programmed cell death 1 (PDCD1; also known as PD-1) elicits durable tumor regression in metastatic cancer, but these dramatic responses are confined to a minority of patients. This suboptimal outcome is probably due in part to the complex network of immunosuppressive pathways present in advanced tumors, which are unlikely to be overcome by intervention at a single signaling checkpoint. Here we describe a combination immunotherapy that recruits a variety of innate and adaptive immune cells to eliminate large tumor burdens in syngeneic tumor models and a genetically engineered mouse model of melanoma; to our knowledge tumors of this size have not previously been curable by treatments relying on endogenous immunity. Maximal antitumor efficacy required four components: a tumor-antigen-targeting antibody, a recombinant interleukin-2 with an extended half-life, anti-PD-1 and a powerful T cell vaccine. Depletion experiments revealed that CD8(+) T cells, cross-presenting dendritic cells and several other innate immune cell subsets were required for tumor regression. Effective treatment induced infiltration of immune cells and production of inflammatory cytokines in the tumor, enhanced antibody-mediated tumor antigen uptake and promoted antigen spreading. These results demonstrate the capacity of an elicited endogenous immune response to destroy large, established tumors and elucidate essential characteristics of combination immunotherapies that are capable of curing a majority of tumors in experimental settings typically viewed as intractable. Twit Text FOAVip Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=27775706 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27775706 #FOAvip English Wikipedia <ref>{{Cite pmid|27775706 }}</ref> Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses #MMPMID27775706 Moynihan KD ; Opel CF ; Szeto GL ; Tzeng A ; Zhu EF ; Engreitz JM ; Williams RT ; Rakhra K ; Zhang MH ; Rothschilds AM ; Kumari S ; Kelly RL ; Kwan BH ; Abraham W ; Hu K ; Mehta NK ; Kauke MJ ; Suh H ; Cochran JR ; Lauffenburger DA ; Wittrup KD ; Irvine DJ Nat Med 2016[Dec]; 22 (12 ): 1402-1410 PMID27775706 show ga Checkpoint blockade with antibodies specific for cytotoxic T lymphocyte-associated protein (CTLA)-4 or programmed cell death 1 (PDCD1; also known as PD-1) elicits durable tumor regression in metastatic cancer, but these dramatic responses are confined to a minority of patients. This suboptimal outcome is probably due in part to the complex network of immunosuppressive pathways present in advanced tumors, which are unlikely to be overcome by intervention at a single signaling checkpoint. Here we describe a combination immunotherapy that recruits a variety of innate and adaptive immune cells to eliminate large tumor burdens in syngeneic tumor models and a genetically engineered mouse model of melanoma; to our knowledge tumors of this size have not previously been curable by treatments relying on endogenous immunity. Maximal antitumor efficacy required four components: a tumor-antigen-targeting antibody, a recombinant interleukin-2 with an extended half-life, anti-PD-1 and a powerful T cell vaccine. Depletion experiments revealed that CD8(+) T cells, cross-presenting dendritic cells and several other innate immune cell subsets were required for tumor regression. Effective treatment induced infiltration of immune cells and production of inflammatory cytokines in the tumor, enhanced antibody-mediated tumor antigen uptake and promoted antigen spreading. These results demonstrate the capacity of an elicited endogenous immune response to destroy large, established tumors and elucidate essential characteristics of combination immunotherapies that are capable of curing a majority of tumors in experimental settings typically viewed as intractable. |Adaptive Immunity [MESH] |Animals [MESH] |Antineoplastic Agents/*pharmacology [MESH] |Cancer Vaccines/*pharmacology [MESH] |Cell Line, Tumor [MESH] |Cytokines/*drug effects/immunology [MESH] |Drug Therapy, Combination [MESH] |Flow Cytometry [MESH] |Gene Knockout Techniques [MESH] |Immunity, Innate [MESH] |Immunoblotting [MESH] |Immunotherapy/*methods [MESH] |Interleukin-2/*pharmacology [MESH] |Intramolecular Oxidoreductases/genetics [MESH] |Lung Neoplasms/*drug therapy [MESH] |Mammary Neoplasms, Experimental/*drug therapy [MESH] |Melanoma, Experimental/*drug therapy [MESH] |Mice [MESH] |Programmed Cell Death 1 Receptor/*antagonists & inhibitors [MESH]Eradication of large established tumors in mice by combination immunot(epmc).pdf DeepDyve Pubget Overpricing