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10.1016/j.neurobiolaging.2016.11.002 http://scihub22266oqcxt.onion/10.1016/j.neurobiolaging.2016.11.002 C5209254!5209254 !27940353     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27940353 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Neurobiol+Aging 2017 ; 50 (ä): 96-106 Nephropedia Template TP {{tp|p=27940353 |t=2017. White matter damage and glymphatic dysfunction in a model of vascular dementia in rats with no prior vascular pathologies |pdf=|usr=}}{{27940353 }} gab.com Text White matter damage and glymphatic dysfunction in a model of vascular dementia in rats with no prior vascular pathologies JO: Neurobiol Aging http://www.kidney.de/pget.php?&tw=1&pmid=27940353 #FOAvip We investigated cognitive function, axonal/white matter (WM) changes and glymphatic function of vascular dementia using a multiple microinfarction (MMI) model in retired breeder (RB) rats. The MMI model induces significant (p < 0.05) cognitive decline that worsens with age starting at 2 weeks, which persists until at least 6 weeks after MMI. RB rats subjected to MMI exhibit significant axonal/WM damage identified by decreased myelin thickness, oligodendrocyte progenitor cell numbers, axon density, synaptic protein expression in the cortex and striatum, cortical neuronal branching, and dendritic spine density in the cortex and hippocampus compared with age-matched controls. MMI evokes significant dilation of perivascular spaces as well as water channel dysfunction indicated by decreased Aquaporin-4 expression around blood vessels. MMI-induced glymphatic dysfunction with delayed cerebrospinal fluid penetration into the brain parenchyma via paravascular pathways as well as delayed waste clearance from the brain. The MMI model in RB rats decreases Aquaporin-4 and induces glymphatic dysfunction which may play an important role in MMI-induced axonal/WM damage and cognitive deficits. Twit Text FOAVip White matter damage and glymphatic dysfunction in a model of vascular dementia in rats with no prior vascular pathologies ????Neurobiol Aging http://www.kidney.de/pget.php?&tw=1&pmid=27940353 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27940353 #FOAvip English Wikipedia <ref>{{Cite pmid|27940353 }}</ref> White matter damage and glymphatic dysfunction in a model of vascular dementia in rats with no prior vascular pathologies #MMPMID27940353 Venkat P ; Chopp M ; Zacharek A ; Cui C ; Zhang L ; Li Q ; Lu M ; Zhang T ; Liu A ; Chen J Neurobiol Aging 2017[Feb]; 50 (ä): 96-106 PMID27940353 show ga We investigated cognitive function, axonal/white matter (WM) changes and glymphatic function of vascular dementia using a multiple microinfarction (MMI) model in retired breeder (RB) rats. The MMI model induces significant (p < 0.05) cognitive decline that worsens with age starting at 2 weeks, which persists until at least 6 weeks after MMI. RB rats subjected to MMI exhibit significant axonal/WM damage identified by decreased myelin thickness, oligodendrocyte progenitor cell numbers, axon density, synaptic protein expression in the cortex and striatum, cortical neuronal branching, and dendritic spine density in the cortex and hippocampus compared with age-matched controls. MMI evokes significant dilation of perivascular spaces as well as water channel dysfunction indicated by decreased Aquaporin-4 expression around blood vessels. MMI-induced glymphatic dysfunction with delayed cerebrospinal fluid penetration into the brain parenchyma via paravascular pathways as well as delayed waste clearance from the brain. The MMI model in RB rats decreases Aquaporin-4 and induces glymphatic dysfunction which may play an important role in MMI-induced axonal/WM damage and cognitive deficits. |Aging/*pathology [MESH] |Animals [MESH] |Aquaporin 4/metabolism [MESH] |Axons/pathology [MESH] |Brain/metabolism/pathology [MESH] |Cerebrospinal Fluid/metabolism [MESH] |Cognition [MESH] |Dementia, Vascular/*etiology/*pathology/physiopathology/psychology [MESH] |Disease Models, Animal [MESH] |Lymphatic System/*physiology [MESH] |Male [MESH] |Myelin Sheath/pathology [MESH] |Neuroglia/*physiology [MESH] |Oligodendroglia/pathology [MESH] |Rats, Wistar [MESH]White matter damage and glymphatic dysfunction in a model of vascular (epmc).pdf DeepDyve Pubget Overpricing