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10.1002/eji.201646475 http://scihub22266oqcxt.onion/10.1002/eji.201646475 C5208044!5208044!27354309     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2016 ; 46 (9): 2103-10 Nephropedia Template TP {{tp|p=27354309|t=2016. Targeted loss of SHP1 in murine thymocytes dampens TCR signaling late in selection |pdf=|usr=}}{{27354309}} gab.com Text Targeted loss of SHP1 in murine thymocytes dampens TCR signaling late in selection JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27354309 #FOAvip SHP1 is a tyrosine phosphatase critical to proximal regulation of TCR signaling. Here, analysis of CD4-Cre SHP1fl/fl conditional knockout thymocytes using CD53, TCR?, CD69, CD4 and CD8? expression demonstrates the importance of SHP1 in the survival of post selection (CD53+), single-positive thymocytes. Using Ca2+ flux to assess the intensity of TCR signaling demonstrated that SHP1 dampens the signal strength of these same mature, post-selection thymocytes. Consistent with its dampening effect, TCR signal strength was also probed functionally using peptides that can mediate selection of the OT-I TCR, to reveal increased negative selection mediated by lower-affinity ligand in the absence of SHP1. Our data show that SHP1 is required for the survival of mature thymocytes and the generation of the functional T-cell repertoire, as its absence leads to a reduction in the numbers of CD4+ and CD8+ naïve T cells in the peripheral lymphoid compartments. Twit Text FOAVip Targeted loss of SHP1 in murine thymocytes dampens TCR signaling late in selection ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27354309 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27354309 #FOAvip English Wikipedia <ref>{{Cite pmid|27354309}}</ref> Targeted loss of SHP1 in murine thymocytes dampens TCR signaling late in selection #MMPMID27354309 Martinez RJ; Morris AB; Neeld DK; Evavold BD Eur J Immunol 2016[Sep]; 46 (9): 2103-10 PMID27354309show ga SHP1 is a tyrosine phosphatase critical to proximal regulation of TCR signaling. Here, analysis of CD4-Cre SHP1fl/fl conditional knockout thymocytes using CD53, TCR?, CD69, CD4 and CD8? expression demonstrates the importance of SHP1 in the survival of post selection (CD53+), single-positive thymocytes. Using Ca2+ flux to assess the intensity of TCR signaling demonstrated that SHP1 dampens the signal strength of these same mature, post-selection thymocytes. Consistent with its dampening effect, TCR signal strength was also probed functionally using peptides that can mediate selection of the OT-I TCR, to reveal increased negative selection mediated by lower-affinity ligand in the absence of SHP1. Our data show that SHP1 is required for the survival of mature thymocytes and the generation of the functional T-cell repertoire, as its absence leads to a reduction in the numbers of CD4+ and CD8+ naïve T cells in the peripheral lymphoid compartments. äTargeted loss of SHP1 in murine thymocytes dampens TCR signaling late (epmc).pdf DeepDyve Pubget Overpricing