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10.1074/jbc.M116.746396 http://scihub22266oqcxt.onion/10.1074/jbc.M116.746396 C5207054!5207054 !27803166     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27803166 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2016 ; 291 (50 ): 25789-25798 Nephropedia Template TP {{tp|p=27803166 |t=2016. Borna Disease Virus Assembles Porous Cage-like Viral Factories in the Nucleus |pdf=|usr=}}{{27803166 }} gab.com Text Borna Disease Virus Assembles Porous Cage-like Viral Factories in the Nucleus JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27803166 #FOAvip Animal-derived RNA viruses frequently generate viral factories in infected cells. However, the details of how RNA viruses build such intracellular structures are poorly understood. In this study, we examined the structure and formation of the viral factories, called viral speckle of transcripts (vSPOTs), that are produced in the nuclei of host cells by Borna disease virus (BDV). Super-resolution microscopic analysis showed that BDV assembled vSPOTs as intranuclear cage-like structures with 59-180-nm pores. The viral nucleoprotein formed the exoskeletons of vSPOTs, whereas the other viral proteins appeared to be mainly localized within these structures. In addition, stochastic optical reconstruction microscopy revealed that filamentous structures resembling viral ribonucleoprotein complexes (RNPs) appeared to protrude from the outer surfaces of the vSPOTs. We also found that vSPOTs disintegrated into RNPs concurrently with the breakdown of the nuclear envelope during mitosis. These observations demonstrated that BDV generates viral replication factories whose shape and formation are regulated, suggesting the mechanism of the integrity of RNA virus persistent infection in the nucleus. Twit Text FOAVip Borna Disease Virus Assembles Porous Cage-like Viral Factories in the Nucleus ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27803166 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27803166 #FOAvip English Wikipedia <ref>{{Cite pmid|27803166 }}</ref> Borna Disease Virus Assembles Porous Cage-like Viral Factories in the Nucleus #MMPMID27803166 Hirai Y ; Hirano Y ; Matsuda A ; Hiraoka Y ; Honda T ; Tomonaga K J Biol Chem 2016[Dec]; 291 (50 ): 25789-25798 PMID27803166 show ga Animal-derived RNA viruses frequently generate viral factories in infected cells. However, the details of how RNA viruses build such intracellular structures are poorly understood. In this study, we examined the structure and formation of the viral factories, called viral speckle of transcripts (vSPOTs), that are produced in the nuclei of host cells by Borna disease virus (BDV). Super-resolution microscopic analysis showed that BDV assembled vSPOTs as intranuclear cage-like structures with 59-180-nm pores. The viral nucleoprotein formed the exoskeletons of vSPOTs, whereas the other viral proteins appeared to be mainly localized within these structures. In addition, stochastic optical reconstruction microscopy revealed that filamentous structures resembling viral ribonucleoprotein complexes (RNPs) appeared to protrude from the outer surfaces of the vSPOTs. We also found that vSPOTs disintegrated into RNPs concurrently with the breakdown of the nuclear envelope during mitosis. These observations demonstrated that BDV generates viral replication factories whose shape and formation are regulated, suggesting the mechanism of the integrity of RNA virus persistent infection in the nucleus. |Animals [MESH] |Borna disease virus/*metabolism [MESH] |Cell Line [MESH] |Cell Nucleus/*metabolism/virology [MESH] |Nucleoproteins/*metabolism [MESH]Borna Disease Virus Assembles Porous Cage-like Viral Factories in the (epmc).pdf DeepDyve Pubget Overpricing