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10.1038/ng.3726 http://scihub22266oqcxt.onion/10.1038/ng.3726 C5206905!5206905!27869828     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Genet 2017 ; 49 (1): 10-6 Nephropedia Template TP {{tp|p=27869828|t=2017. Tumor suppressor genes that escape from X-inactivation contribute to cancer sex bias |pdf=|usr=}}{{27869828}} gab.com Text Tumor suppressor genes that escape from X-inactivation contribute to cancer sex bias JO: Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=27869828 #FOAvip There is a striking and unexplained male predominance across many cancer types. A subset of X chromosome (chrX) genes can escape X-inactivation, which would protect females from complete functional loss by a single mutation. To identify putative ?Escape from X-Inactivation Tumor Suppressor? (EXITS) genes, we compared somatic alterations from >4100 cancers across 21 tumor types for sex bias. Six of 783 non-pseudoautosomal region (PAR) chrX genes (ATRX, CNKSR2, DDX3X, KDM5C, KDM6A, and MAGEC3) more frequently harbored loss-of-function mutations in males (based on false discovery rate <0.1), compared to zero of 18,055 autosomal and PAR genes (P<0.0001). Male-biased mutations in genes that escape X-inactivation were observed in combined analysis across many cancers and in several individual tumor types, suggesting a generalized phenomenon. We conclude that biallelic expression of EXITS genes in females explains a portion of the reduced cancer incidence compared to males across a variety of tumor types. Twit Text FOAVip Tumor suppressor genes that escape from X-inactivation contribute to cancer sex bias ????Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=27869828 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27869828 #FOAvip English Wikipedia <ref>{{Cite pmid|27869828}}</ref> Tumor suppressor genes that escape from X-inactivation contribute to cancer sex bias #MMPMID27869828 Dunford A; Weinstock DM; Savova V; Schumacher SE; Cleary JP; Yoda A; Sullivan TJ; Hess JM; Gimelbrant AA; Beroukhim R; Lawrence MS; Getz G; Lane AA Nat Genet 2017[Jan]; 49 (1): 10-6 PMID27869828show ga There is a striking and unexplained male predominance across many cancer types. A subset of X chromosome (chrX) genes can escape X-inactivation, which would protect females from complete functional loss by a single mutation. To identify putative ?Escape from X-Inactivation Tumor Suppressor? (EXITS) genes, we compared somatic alterations from >4100 cancers across 21 tumor types for sex bias. Six of 783 non-pseudoautosomal region (PAR) chrX genes (ATRX, CNKSR2, DDX3X, KDM5C, KDM6A, and MAGEC3) more frequently harbored loss-of-function mutations in males (based on false discovery rate <0.1), compared to zero of 18,055 autosomal and PAR genes (P<0.0001). Male-biased mutations in genes that escape X-inactivation were observed in combined analysis across many cancers and in several individual tumor types, suggesting a generalized phenomenon. We conclude that biallelic expression of EXITS genes in females explains a portion of the reduced cancer incidence compared to males across a variety of tumor types. äTumor suppressor genes that escape from X-inactivation contribute to c(epmc).pdf DeepDyve Pubget Overpricing