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10.1084/jem.20161228

http://scihub22266oqcxt.onion/10.1084/jem.20161228
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C5206503!5206503!27994071
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suck abstract from ncbi


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pmid27994071      J+Exp+Med 2017 ; 214 (1): 59-71
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  • Autoinflammatory periodic fever, immunodeficiency, and thrombocytopenia (PFIT) caused by mutation in actin-regulatory gene WDR1 #MMPMID27994071
  • Standing AS; Malinova D; Hong Y; Record J; Moulding D; Blundell MP; Nowak K; Jones H; Omoyinmi E; Gilmour KC; Medlar A; Stanescu H; Kleta R; Anderson G; Nanthapisal S; Gomes SM; Klein N; Eleftheriou D; Thrasher AJ; Brogan PA
  • J Exp Med 2017[Jan]; 214 (1): 59-71 PMID27994071show ga
  • Standing et al. report a novel autoinflammatory disease caused by a homozygous missense mutation in the actin-regulating protein WDR1. The disease is characterized by periodic fevers, immunodeficiency, and thrombocytopenia, with increased polymerized actin in immune cells and increased IL-18 secretion.
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