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10.1101/gr.209015.116 http://scihub22266oqcxt.onion/10.1101/gr.209015.116 C5204348!5204348!27821408     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genome+Res 2017 ; 27 (1): 95-106 Nephropedia Template TP {{tp|p=27821408|t=2017. A novel translational control mechanism involving RNA structures within coding sequences |pdf=|usr=}}{{27821408}} gab.com Text A novel translational control mechanism involving RNA structures within coding sequences JO: Genome Res http://www.kidney.de/pget.php?&tw=1&pmid=27821408 #FOAvip The impact of RNA structures in coding sequences (CDS) within mRNAs is poorly understood. Here, we identify a novel and highly conserved mechanism of translational control involving RNA structures within coding sequences and the DEAD-box helicase Dhh1. Using yeast genetics and genome-wide ribosome profiling analyses, we show that this mechanism, initially derived from studies of the Brome Mosaic virus RNA genome, extends to yeast and human mRNAs highly enriched in membrane and secreted proteins. All Dhh1-dependent mRNAs, viral and cellular, share key common features. First, they contain long and highly structured CDSs, including a region located around nucleotide 70 after the translation initiation site; second, they are directly bound by Dhh1 with a specific binding distribution; and third, complementary experimental approaches suggest that they are activated by Dhh1 at the translation initiation step. Our results show that ribosome translocation is not the only unwinding force of CDS and uncover a novel layer of translational control that involves RNA helicases and RNA folding within CDS providing novel opportunities for regulation of membrane and secretome proteins. Twit Text FOAVip A novel translational control mechanism involving RNA structures within coding sequences ????Genome Res http://www.kidney.de/pget.php?&tw=1&pmid=27821408 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27821408 #FOAvip English Wikipedia <ref>{{Cite pmid|27821408}}</ref> A novel translational control mechanism involving RNA structures within coding sequences #MMPMID27821408 Jungfleisch J; Nedialkova DD; Dotu I; Sloan KE; Martinez-Bosch N; Brüning L; Raineri E; Navarro P; Bohnsack MT; Leidel SA; Díez J Genome Res 2017[Jan]; 27 (1): 95-106 PMID27821408show ga The impact of RNA structures in coding sequences (CDS) within mRNAs is poorly understood. Here, we identify a novel and highly conserved mechanism of translational control involving RNA structures within coding sequences and the DEAD-box helicase Dhh1. Using yeast genetics and genome-wide ribosome profiling analyses, we show that this mechanism, initially derived from studies of the Brome Mosaic virus RNA genome, extends to yeast and human mRNAs highly enriched in membrane and secreted proteins. All Dhh1-dependent mRNAs, viral and cellular, share key common features. First, they contain long and highly structured CDSs, including a region located around nucleotide 70 after the translation initiation site; second, they are directly bound by Dhh1 with a specific binding distribution; and third, complementary experimental approaches suggest that they are activated by Dhh1 at the translation initiation step. Our results show that ribosome translocation is not the only unwinding force of CDS and uncover a novel layer of translational control that involves RNA helicases and RNA folding within CDS providing novel opportunities for regulation of membrane and secretome proteins. äA novel translational control mechanism involving RNA structures withi(epmc).pdf DeepDyve Pubget Overpricing