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10.1172/JCI90745 http://scihub22266oqcxt.onion/10.1172/JCI90745 C5199717!5199717!27941247     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest ä ; 127 (1): 269-79 Nephropedia Template TP {{tp|p=27941247|t=ä. Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs |pdf=|usr=}}{{27941247}} gab.com Text Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=27941247 #FOAvip Despite the efficient suppression of HIV-1 replication that can be achieved with combined antiretroviral therapy (cART), low levels of type I interferon (IFN-I) signaling persist in some individuals. This sustained signaling may impede immune recovery and foster viral persistence. Here we report studies using a monoclonal antibody to block IFN-?/? receptor (IFNAR) signaling in humanized mice (hu-mice) that were persistently infected with HIV-1. We discovered that effective cART restored the number of human immune cells in HIV-1?infected hu-mice but did not rescue their immune hyperactivation and dysfunction. IFNAR blockade fully reversed HIV-1?induced immune hyperactivation and rescued anti?HIV-1 immune responses in T cells from HIV-1?infected hu-mice. Finally, we found that IFNAR blockade in the presence of cART reduced the size of HIV-1 reservoirs in lymphoid tissues and delayed HIV-1 rebound after cART cessation in the HIV-1?infected hu-mice. We conclude that low levels of IFN-I signaling contribute to HIV-1?associated immune dysfunction and foster HIV-1 persistence in cART-treated hosts. Our results suggest that blocking IFNAR may provide a potential strategy to enhance immune recovery and reduce HIV-1 reservoirs in individuals with sustained elevations in IFN-I signaling during suppressive cART. Twit Text FOAVip Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=27941247 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27941247 #FOAvip English Wikipedia <ref>{{Cite pmid|27941247}}</ref> Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs #MMPMID27941247 Cheng L; Ma J; Li J; Li D; Li G; Li F; Zhang Q; Yu H; Yasui F; Ye C; Tsao LC; Hu Z; Su L; Zhang L J Clin Invest ä[]; 127 (1): 269-79 PMID27941247show ga Despite the efficient suppression of HIV-1 replication that can be achieved with combined antiretroviral therapy (cART), low levels of type I interferon (IFN-I) signaling persist in some individuals. This sustained signaling may impede immune recovery and foster viral persistence. Here we report studies using a monoclonal antibody to block IFN-?/? receptor (IFNAR) signaling in humanized mice (hu-mice) that were persistently infected with HIV-1. We discovered that effective cART restored the number of human immune cells in HIV-1?infected hu-mice but did not rescue their immune hyperactivation and dysfunction. IFNAR blockade fully reversed HIV-1?induced immune hyperactivation and rescued anti?HIV-1 immune responses in T cells from HIV-1?infected hu-mice. Finally, we found that IFNAR blockade in the presence of cART reduced the size of HIV-1 reservoirs in lymphoid tissues and delayed HIV-1 rebound after cART cessation in the HIV-1?infected hu-mice. We conclude that low levels of IFN-I signaling contribute to HIV-1?associated immune dysfunction and foster HIV-1 persistence in cART-treated hosts. Our results suggest that blocking IFNAR may provide a potential strategy to enhance immune recovery and reduce HIV-1 reservoirs in individuals with sustained elevations in IFN-I signaling during suppressive cART. äBlocking type I interferon signaling enhances T cell recovery and redu(epmc).pdf DeepDyve Pubget Overpricing