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10.1172/JCI88015 http://scihub22266oqcxt.onion/10.1172/JCI88015 C5199694!5199694!27941241     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest ä ; 127 (1): 230-43 Nephropedia Template TP {{tp|p=27941241|t=ä. PAX6 maintains ? cell identity by repressing genes of alternative islet cell types |pdf=|usr=}}{{27941241}} gab.com Text PAX6 maintains cell identity by repressing genes of alternative islet cell types JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=27941241 #FOAvip Type 2 diabetes is thought to involve a compromised ? cell differentiation state, but the mechanisms underlying this dysfunction remain unclear. Here, we report a key role for the TF PAX6 in the maintenance of adult ? cell identity and function. PAX6 was downregulated in ? cells of diabetic db/db mice and in WT mice treated with an insulin receptor antagonist, revealing metabolic control of expression. Deletion of Pax6 in ? cells of adult mice led to lethal hyperglycemia and ketosis that were attributed to loss of ? cell function and expansion of ? cells. Lineage-tracing, transcriptome, and chromatin analyses showed that PAX6 is a direct activator of ? cell genes, thus maintaining mature ? cell function and identity. In parallel, we found that PAX6 binds promoters and enhancers to repress alternative islet cell genes including ghrelin, glucagon, and somatostatin. Chromatin analysis and shRNA-mediated gene suppression experiments indicated a similar function of PAX6 in human ? cells. We conclude that reduced expression of PAX6 in metabolically stressed ? cells may contribute to ? cell failure and ? cell dysfunction in diabetes. Twit Text FOAVip PAX6 maintains cell identity by repressing genes of alternative islet cell types ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=27941241 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27941241 #FOAvip English Wikipedia <ref>{{Cite pmid|27941241}}</ref> PAX6 maintains ? cell identity by repressing genes of alternative islet cell types #MMPMID27941241 Swisa A; Avrahami D; Eden N; Zhang J; Feleke E; Dahan T; Cohen-Tayar Y; Stolovich-Rain M; Kaestner KH; Glaser B; Ashery-Padan R; Dor Y J Clin Invest ä[]; 127 (1): 230-43 PMID27941241show ga Type 2 diabetes is thought to involve a compromised ? cell differentiation state, but the mechanisms underlying this dysfunction remain unclear. Here, we report a key role for the TF PAX6 in the maintenance of adult ? cell identity and function. PAX6 was downregulated in ? cells of diabetic db/db mice and in WT mice treated with an insulin receptor antagonist, revealing metabolic control of expression. Deletion of Pax6 in ? cells of adult mice led to lethal hyperglycemia and ketosis that were attributed to loss of ? cell function and expansion of ? cells. Lineage-tracing, transcriptome, and chromatin analyses showed that PAX6 is a direct activator of ? cell genes, thus maintaining mature ? cell function and identity. In parallel, we found that PAX6 binds promoters and enhancers to repress alternative islet cell genes including ghrelin, glucagon, and somatostatin. Chromatin analysis and shRNA-mediated gene suppression experiments indicated a similar function of PAX6 in human ? cells. We conclude that reduced expression of PAX6 in metabolically stressed ? cells may contribute to ? cell failure and ? cell dysfunction in diabetes. äPAX6 maintains ? cell identity by repressing genes of alternative isle(epmc).pdf DeepDyve Pubget Overpricing