Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1172/JCI88668 http://scihub22266oqcxt.onion/10.1172/JCI88668 C5199691!5199691!27869650     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest ä ; 127 (1): 132-6 Nephropedia Template TP {{tp|p=27869650|t=ä. Inhibiting mitochondrial respiration prevents cancer in a mouse model of Li-Fraumeni syndrome |pdf=|usr=}}{{27869650}} gab.com Text Inhibiting mitochondrial respiration prevents cancer in a mouse model of Li-Fraumeni syndrome JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=27869650 #FOAvip Li-Fraumeni syndrome (LFS) is a cancer predisposition disorder caused by germline mutations in TP53 that can lead to increased mitochondrial metabolism in patients. However, the implications of altered mitochondrial function for tumorigenesis in LFS are unclear. Here, we have reported that genetic or pharmacologic disruption of mitochondrial respiration improves cancer-free survival in a mouse model of LFS that expresses mutant p53. Mechanistically, inhibition of mitochondrial function increased autophagy and decreased the aberrant proliferation signaling caused by mutant p53. In a pilot study, LFS patients treated with metformin exhibited decreases in mitochondrial activity concomitant with activation of antiproliferation signaling, thus reproducing the effects of disrupting mitochondrial function observed in LFS mice. These observations indicate that a commonly prescribed diabetic medicine can restrain mitochondrial metabolism and tumorigenesis in an LFS model, supporting its further consideration for cancer prevention in LFS patients. Twit Text FOAVip Inhibiting mitochondrial respiration prevents cancer in a mouse model of Li-Fraumeni syndrome ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=27869650 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27869650 #FOAvip English Wikipedia <ref>{{Cite pmid|27869650}}</ref> Inhibiting mitochondrial respiration prevents cancer in a mouse model of Li-Fraumeni syndrome #MMPMID27869650 Wang Py; Li J; Walcott FL; Kang JG; Starost MF; Talagala SL; Zhuang J; Park JH; Huffstutler RD; Bryla CM; Mai PL; Pollak M; Annunziata CM; Savage SA; Fojo AT; Hwang PM J Clin Invest ä[]; 127 (1): 132-6 PMID27869650show ga Li-Fraumeni syndrome (LFS) is a cancer predisposition disorder caused by germline mutations in TP53 that can lead to increased mitochondrial metabolism in patients. However, the implications of altered mitochondrial function for tumorigenesis in LFS are unclear. Here, we have reported that genetic or pharmacologic disruption of mitochondrial respiration improves cancer-free survival in a mouse model of LFS that expresses mutant p53. Mechanistically, inhibition of mitochondrial function increased autophagy and decreased the aberrant proliferation signaling caused by mutant p53. In a pilot study, LFS patients treated with metformin exhibited decreases in mitochondrial activity concomitant with activation of antiproliferation signaling, thus reproducing the effects of disrupting mitochondrial function observed in LFS mice. These observations indicate that a commonly prescribed diabetic medicine can restrain mitochondrial metabolism and tumorigenesis in an LFS model, supporting its further consideration for cancer prevention in LFS patients. äInhibiting mitochondrial respiration prevents cancer in a mouse model (epmc).pdf DeepDyve Pubget Overpricing