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10.1172/JCI88647 http://scihub22266oqcxt.onion/10.1172/JCI88647 C5199690!5199690!27893460     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest ä ; 127 (1): 280-92 Nephropedia Template TP {{tp|p=27893460|t=ä. TGF-?1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage |pdf=|usr=}}{{27893460}} gab.com Text TGF- 1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=27893460 #FOAvip Intracerebral hemorrhage (ICH) is a devastating form of stroke that results from the rupture of a blood vessel in the brain, leading to a mass of blood within the brain parenchyma. The injury causes a rapid inflammatory reaction that includes activation of the tissue-resident microglia and recruitment of blood-derived macrophages and other leukocytes. In this work, we investigated the specific responses of microglia following ICH with the aim of identifying pathways that may aid in recovery after brain injury. We used longitudinal transcriptional profiling of microglia in a murine model to determine the phenotype of microglia during the acute and resolution phases of ICH in vivo and found increases in TGF-?1 pathway activation during the resolution phase. We then confirmed that TGF-?1 treatment modulated inflammatory profiles of microglia in vitro. Moreover, TGF-?1 treatment following ICH decreased microglial Il6 gene expression in vivo and improved functional outcomes in the murine model. Finally, we observed that patients with early increases in plasma TGF-?1 concentrations had better outcomes 90 days after ICH, confirming the role of TGF-?1 in functional recovery from ICH. Taken together, our data show that TGF-?1 modulates microglia-mediated neuroinflammation after ICH and promotes functional recovery, suggesting that TGF-?1 may be a therapeutic target for acute brain injury. Twit Text FOAVip TGF- 1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=27893460 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27893460 #FOAvip English Wikipedia <ref>{{Cite pmid|27893460}}</ref> TGF-?1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage #MMPMID27893460 Taylor RA; Chang CF; Goods BA; Hammond MD; Grory BM; Ai Y; Steinschneider AF; Renfroe SC; Askenase MH; McCullough LD; Kasner SE; Mullen MT; Hafler DA; Love JC; Sansing LH J Clin Invest ä[]; 127 (1): 280-92 PMID27893460show ga Intracerebral hemorrhage (ICH) is a devastating form of stroke that results from the rupture of a blood vessel in the brain, leading to a mass of blood within the brain parenchyma. The injury causes a rapid inflammatory reaction that includes activation of the tissue-resident microglia and recruitment of blood-derived macrophages and other leukocytes. In this work, we investigated the specific responses of microglia following ICH with the aim of identifying pathways that may aid in recovery after brain injury. We used longitudinal transcriptional profiling of microglia in a murine model to determine the phenotype of microglia during the acute and resolution phases of ICH in vivo and found increases in TGF-?1 pathway activation during the resolution phase. We then confirmed that TGF-?1 treatment modulated inflammatory profiles of microglia in vitro. Moreover, TGF-?1 treatment following ICH decreased microglial Il6 gene expression in vivo and improved functional outcomes in the murine model. Finally, we observed that patients with early increases in plasma TGF-?1 concentrations had better outcomes 90 days after ICH, confirming the role of TGF-?1 in functional recovery from ICH. Taken together, our data show that TGF-?1 modulates microglia-mediated neuroinflammation after ICH and promotes functional recovery, suggesting that TGF-?1 may be a therapeutic target for acute brain injury. äTGF-?1 modulates microglial phenotype and promotes recovery after intr(epmc).pdf DeepDyve Pubget Overpricing