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10.1016/j.devcel.2016.10.001 http://scihub22266oqcxt.onion/10.1016/j.devcel.2016.10.001 C5198784!5198784!27840107     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Dev+Cell 2016 ; 39 (4): 480-90 Nephropedia Template TP {{tp|p=27840107|t=2016. Single-cell Resolution of Temporal Gene Expression during Heart Development |pdf=|usr=}}{{27840107}} gab.com Text Single-cell Resolution of Temporal Gene Expression during Heart Development JO: Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=27840107 #FOAvip Activation of complex molecular programs in specific cell lineages governs mammalian heart development, from a primordial linear tube to a four-chamber organ. To characterize lineage-specific, temporal-spatial developmental programs, we performed single-cell RNA sequencing of >1200 murine cells isolated at seven time points spanning E9.5 (primordial heart tube) to P21 (mature heart). Using unbiased transcriptional data we classified cardiomyocytes (CM), endothelial cells (EC), and fibroblast-enriched cells, thus identifying markers for temporal and chamber-specific developmental programs. Harnessing these datasets, we defined developmental ages of human and mouse pluripotent stem cell-derived CMs and characterized lineage-specific maturation defects in hearts of mice with heterozygous mutations in Nkx2.5 that cause human heart malformations. This spatial-temporal transcriptome analysis of heart development reveals lineage-specific gene programs underlying normal cardiac development and congenital heart disease. Twit Text FOAVip Single-cell Resolution of Temporal Gene Expression during Heart Development ????Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=27840107 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27840107 #FOAvip English Wikipedia <ref>{{Cite pmid|27840107}}</ref> Single-cell Resolution of Temporal Gene Expression during Heart Development #MMPMID27840107 DeLaughter DM; Bick AG; Wakimoto H; McKean D; Gorham JM; Kathiriya IS; Hinson JT; Homsy J; Gray J; Pu W; Bruneau BG; Seidman JG; Seidman CE Dev Cell 2016[Nov]; 39 (4): 480-90 PMID27840107show ga Activation of complex molecular programs in specific cell lineages governs mammalian heart development, from a primordial linear tube to a four-chamber organ. To characterize lineage-specific, temporal-spatial developmental programs, we performed single-cell RNA sequencing of >1200 murine cells isolated at seven time points spanning E9.5 (primordial heart tube) to P21 (mature heart). Using unbiased transcriptional data we classified cardiomyocytes (CM), endothelial cells (EC), and fibroblast-enriched cells, thus identifying markers for temporal and chamber-specific developmental programs. Harnessing these datasets, we defined developmental ages of human and mouse pluripotent stem cell-derived CMs and characterized lineage-specific maturation defects in hearts of mice with heterozygous mutations in Nkx2.5 that cause human heart malformations. This spatial-temporal transcriptome analysis of heart development reveals lineage-specific gene programs underlying normal cardiac development and congenital heart disease. äSingle-cell Resolution of Temporal Gene Expression during Heart Develo(epmc).pdf DeepDyve Pubget Overpricing