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10.1038/ng.3728 http://scihub22266oqcxt.onion/10.1038/ng.3728 C5195898!5195898!27869830     free     free     free       Nat+Genet 2017 ; 49 (1): 87-96 Nephropedia Template TP {{tp|p=27869830|t=2017. Inactivation of Capicua drives cancer metastasis |pdf=|usr=}}{{27869830}} gab.com Text Inactivation of Capicua drives cancer metastasis JO: Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=27869830 #FOAvip Metastasis is the leading cause of death in lung cancer patients, yet the molecular effectors underlying tumor dissemination remain poorly defined. Through development of an in vivo spontaneous lung cancer metastasis model, we show that the developmentally-regulated transcriptional repressor Capicua (CIC) suppresses invasion and metastasis. CIC inactivation relieves repression of its effector ETV4, driving ETV4-mediated upregulation of MMP24 that is necessary and sufficient for metastasis. Loss of CIC, or increased levels of its effectors ETV4 and MMP24, is a biomarker of tumor progression and worse outcomes in lung and gastric cancer patients. Our findings uncover CIC as a conserved metastasis suppressor, revealing new anti-metastatic strategies to improve patient outcomes. Twit Text FOAVip Inactivation of Capicua drives cancer metastasis ????Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=27869830 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27869830 #FOAvip English Wikipedia <ref>{{Cite pmid|27869830}}</ref> Inactivation of Capicua drives cancer metastasis #MMPMID27869830 Okimoto RA; Breitenbuecher F; Olivas VR; Wu W; Gini B; Hofree M; Asthana S; Hrustanovic G; Flanagan J; Tulpule A; Blakely CM; Haringsma HJ; Simmons AD; Gowen K; Suh J; Miller VA; Ali S; Schuler M; Bivona TG Nat Genet 2017[Jan]; 49 (1): 87-96 PMID27869830show ga Metastasis is the leading cause of death in lung cancer patients, yet the molecular effectors underlying tumor dissemination remain poorly defined. Through development of an in vivo spontaneous lung cancer metastasis model, we show that the developmentally-regulated transcriptional repressor Capicua (CIC) suppresses invasion and metastasis. CIC inactivation relieves repression of its effector ETV4, driving ETV4-mediated upregulation of MMP24 that is necessary and sufficient for metastasis. Loss of CIC, or increased levels of its effectors ETV4 and MMP24, is a biomarker of tumor progression and worse outcomes in lung and gastric cancer patients. Our findings uncover CIC as a conserved metastasis suppressor, revealing new anti-metastatic strategies to improve patient outcomes. äInactivation of Capicua drives cancer metastasis (epmc).pdf DeepDyve Pubget Overpricing