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10.1126/science.aad7993 http://scihub22266oqcxt.onion/10.1126/science.aad7993 C5193222!5193222!27127234     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2016 ; 352 (6289): aad7993 Nephropedia Template TP {{tp|p=27127234|t=2016. Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation |pdf=|usr=}}{{27127234}} gab.com Text Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=27127234 #FOAvip The host innate immune response is the first line of defense against pathogens and is orchestrated by the concerted expression of genes induced by microbial stimuli. Deregulated expression of these genes is linked to the initiation and progression of diseases associated with exacerbated inflammation. We identified topoisomerase 1 (Top1) as a positive regulator of RNA polymerase II transcriptional activity at pathogen-induced genes. Depletion or chemical inhibition of Top1 suppresses the host response against influenza and Ebola viruses as well as bacterial products. Therapeutic pharmacological inhibition of Top1 protected mice from death in experimental models of lethal inflammation. Our results indicate that Top1 inhibition could be used as therapy against life-threatening infections characterized by an acutely exacerbated immune response. Twit Text FOAVip Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation ????Science http://www.kidney.de/pget.php?&tw=1&pmid=27127234 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27127234 #FOAvip English Wikipedia <ref>{{Cite pmid|27127234}}</ref> Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation #MMPMID27127234 Rialdi A; Campisi L; Zhao N; Lagda AC; Pietzsch C; Ho JSY; Martinez-Gil L; Fenouil R; Chen X; Edwards M; Metreveli G; Jordan S; Peralta Z; Munoz-Fontela C; Bouvier N; Merad M; Jin J; Weirauch M; Heinz S; Benner C; van Bakel H; Basler C; García-Sastre A; Bukreyev A; Marazzi I Science 2016[May]; 352 (6289): aad7993 PMID27127234show ga The host innate immune response is the first line of defense against pathogens and is orchestrated by the concerted expression of genes induced by microbial stimuli. Deregulated expression of these genes is linked to the initiation and progression of diseases associated with exacerbated inflammation. We identified topoisomerase 1 (Top1) as a positive regulator of RNA polymerase II transcriptional activity at pathogen-induced genes. Depletion or chemical inhibition of Top1 suppresses the host response against influenza and Ebola viruses as well as bacterial products. Therapeutic pharmacological inhibition of Top1 protected mice from death in experimental models of lethal inflammation. Our results indicate that Top1 inhibition could be used as therapy against life-threatening infections characterized by an acutely exacerbated immune response. äTopoisomerase 1 inhibition suppresses inflammatory genes and protects (epmc).pdf DeepDyve Pubget Overpricing