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10.1073/pnas.1612158114

http://scihub22266oqcxt.onion/10.1073/pnas.1612158114
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C5187739!5187739!27930307
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suck abstract from ncbi


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pmid27930307      Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (51): 14787-92
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  • Cosmc is an X-linked inflammatory bowel disease risk gene that spatially regulates gut microbiota and contributes to sex-specific risk #MMPMID27930307
  • Kudelka MR; Hinrichs BH; Darby T; Moreno CS; Nishio H; Cutler CE; Wang J; Wu H; Zeng J; Wang Y; Ju T; Stowell SR; Nusrat A; Jones RM; Neish AS; Cummings RD
  • Proc Natl Acad Sci U S A 2016[Dec]; 113 (51): 14787-92 PMID27930307show ga
  • Inflammatory bowel disease (IBD) is a devastating illness that affects 1.6 million people in the United States and disproportionately affects males in early onset disease. However, IBD genes that contribute to sex-specific risk are unexplored. The gut microbiota interfaces the host with its environment and exhibits alterations in spatial organization in IBD with dysbiosis in the mucosa but a relatively unaffected lumen. Core 1 ?3GalT-specific molecular chaperone (Cosmc) was recently identified as an IBD risk gene on the X chromosome by genome-wide association study. We functionally evaluated Cosmc in IBD and discovered that the loss of Cosmc leads to gut inflammation in males but not females and a spatial pattern of dysbiosis resembling IBD. Thus, Cosmc contributes to sex bias in IBD and spatially regulates the gut microbiota.
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