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10.1073/pnas.1612024114 http://scihub22266oqcxt.onion/10.1073/pnas.1612024114 C5187732!5187732!27930306     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (51): E8286-95 Nephropedia Template TP {{tp|p=27930306|t=2016. miR-17?92 family clusters control iNKT cell ontogenesis via modulation of TGF-? signaling |pdf=|usr=}}{{27930306}} gab.com Text miR-17 92 family clusters control iNKT cell ontogenesis via modulation of TGF- signaling JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27930306 #FOAvip CD1d-restricted invariant natural killer T (iNKT) cells are innate-like T lymphocytes that play fundamental roles in cancer, autoimmunity, and infections. iNKT cells acquire effector functions already in the thymus, because of a distinct developmentally regulated genetic program that is critically controlled by miRNAs. Our study unveils the unexpected requirement for miRNA-dependent fine-tuning of TGF-? signaling in the control of iNKT cell development and functional differentiation. The targeting of a lineage-specific cytokine signaling by miRNA represents a previously unknown level of developmental regulation in the thymus. Furthermore, our study provides a comprehensive atlas of miRNA-regulated molecular pathways involved in iNKT cell ontogenesis, and highlights molecular pathways targeted by defined miRNAs that are predicted to be involved in the development and maturation of CD1d-restricted iNKT cells. Twit Text FOAVip miR-17 92 family clusters control iNKT cell ontogenesis via modulation of TGF- signaling ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27930306 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27930306 #FOAvip English Wikipedia <ref>{{Cite pmid|27930306}}</ref> miR-17?92 family clusters control iNKT cell ontogenesis via modulation of TGF-? signaling #MMPMID27930306 Fedeli M; Riba M; Garcia Manteiga JM; Tian L; Viganò V; Rossetti G; Pagani M; Xiao C; Liston A; Stupka E; Cittaro D; Abrignani S; Provero P; Dellabona P; Casorati G Proc Natl Acad Sci U S A 2016[Dec]; 113 (51): E8286-95 PMID27930306show ga CD1d-restricted invariant natural killer T (iNKT) cells are innate-like T lymphocytes that play fundamental roles in cancer, autoimmunity, and infections. iNKT cells acquire effector functions already in the thymus, because of a distinct developmentally regulated genetic program that is critically controlled by miRNAs. Our study unveils the unexpected requirement for miRNA-dependent fine-tuning of TGF-? signaling in the control of iNKT cell development and functional differentiation. The targeting of a lineage-specific cytokine signaling by miRNA represents a previously unknown level of developmental regulation in the thymus. Furthermore, our study provides a comprehensive atlas of miRNA-regulated molecular pathways involved in iNKT cell ontogenesis, and highlights molecular pathways targeted by defined miRNAs that are predicted to be involved in the development and maturation of CD1d-restricted iNKT cells. ämiR-17?92 family clusters control iNKT cell ontogenesis via modulation(epmc).pdf DeepDyve Pubget Overpricing