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10.1073/pnas.1612024114 http://scihub22266oqcxt.onion/10.1073/pnas.1612024114 C5187732!5187732 !27930306     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27930306 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27930306 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (51 ): E8286-E8295 Nephropedia Template TP {{tp|p=27930306 |t=2016. miR-17?92 family clusters control iNKT cell ontogenesis via modulation of TGF-? signaling |pdf=|usr=}}{{27930306 }} gab.com Text miR-17 92 family clusters control iNKT cell ontogenesis via modulation of TGF- signaling JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27930306 #FOAvip Invariant natural killer T cells (iNKT) cells are T lymphocytes displaying innate effector functions, acquired through a distinct thymic developmental program regulated by microRNAs (miRNAs). Deleting miRNAs by Dicer ablation (Dicer KO) in thymocytes selectively impairs iNKT cell survival and functional differentiation. To unravel this miRNA-dependent program, we systemically identified transcripts that were differentially expressed between WT and Dicer KO iNKT cells at different differentiation stages and predicted to be targeted by the iNKT cell-specific miRNAs. TGF-? receptor II (TGF-?RII), critically implicated in iNKT cell differentiation, was found up-regulated in iNKT Dicer KO cells together with enhanced TGF-? signaling. miRNA members of the miR-17?92 family clusters were predicted to target Tgfbr2 mRNA upon iNKT cell development. iNKT cells lacking all three miR-17?92 family clusters (miR-17?92, miR-106a?363, miR-106b?25) phenocopied both increased TGF-?RII expression and signaling, and defective effector differentiation, displayed by iNKT Dicer KO cells. Consistently, genetic ablation of TGF-? signaling in the absence of miRNAs rescued iNKT cell differentiation. These results elucidate the global impact of miRNAs on the iNKT cell developmental program and uncover the targeting of a lineage-specific cytokine signaling by miRNAs as a mechanism regulating innate-like T-cell development and effector differentiation. Twit Text FOAVip miR-17 92 family clusters control iNKT cell ontogenesis via modulation of TGF- signaling ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27930306 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27930306 #FOAvip English Wikipedia <ref>{{Cite pmid|27930306 }}</ref> miR-17?92 family clusters control iNKT cell ontogenesis via modulation of TGF-? signaling #MMPMID27930306 Fedeli M ; Riba M ; Garcia Manteiga JM ; Tian L ; Vigaṇ V ; Rossetti G ; Pagani M ; Xiao C ; Liston A ; Stupka E ; Cittaro D ; Abrignani S ; Provero P ; Dellabona P ; Casorati G Proc Natl Acad Sci U S A 2016[Dec]; 113 (51 ): E8286-E8295 PMID27930306 show ga Invariant natural killer T cells (iNKT) cells are T lymphocytes displaying innate effector functions, acquired through a distinct thymic developmental program regulated by microRNAs (miRNAs). Deleting miRNAs by Dicer ablation (Dicer KO) in thymocytes selectively impairs iNKT cell survival and functional differentiation. To unravel this miRNA-dependent program, we systemically identified transcripts that were differentially expressed between WT and Dicer KO iNKT cells at different differentiation stages and predicted to be targeted by the iNKT cell-specific miRNAs. TGF-? receptor II (TGF-?RII), critically implicated in iNKT cell differentiation, was found up-regulated in iNKT Dicer KO cells together with enhanced TGF-? signaling. miRNA members of the miR-17?92 family clusters were predicted to target Tgfbr2 mRNA upon iNKT cell development. iNKT cells lacking all three miR-17?92 family clusters (miR-17?92, miR-106a?363, miR-106b?25) phenocopied both increased TGF-?RII expression and signaling, and defective effector differentiation, displayed by iNKT Dicer KO cells. Consistently, genetic ablation of TGF-? signaling in the absence of miRNAs rescued iNKT cell differentiation. These results elucidate the global impact of miRNAs on the iNKT cell developmental program and uncover the targeting of a lineage-specific cytokine signaling by miRNAs as a mechanism regulating innate-like T-cell development and effector differentiation. |Animals [MESH] |Antigens, CD1d/metabolism [MESH] |Cell Differentiation [MESH] |Cytokines/metabolism [MESH] |DEAD-box RNA Helicases/genetics [MESH] |Gene Expression Profiling [MESH] |Genetic Complementation Test [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |MicroRNAs/*genetics [MESH] |Multigene Family [MESH] |Natural Killer T-Cells/*cytology [MESH] |Phenotype [MESH] |RNA, Messenger/metabolism [MESH] |Ribonuclease III/genetics [MESH] |Signal Transduction [MESH] |Thymus Gland/metabolism [MESH]miR-17?92 family clusters control iNKT cell ontogenesis via modulation(epmc).pdf DeepDyve Pubget Overpricing