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10.1073/pnas.1604572113 http://scihub22266oqcxt.onion/10.1073/pnas.1604572113 C5187684!5187684!27911769     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (51): 14710-5 Nephropedia Template TP {{tp|p=27911769|t=2016. Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium |pdf=|usr=}}{{27911769}} gab.com Text Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27911769 #FOAvip In the vertebrate eye, a monolayer of cells, called the retinal pigment epithelium (RPE), is between the choroidal blood supply and the retina. The RPE provides metabolic support for the retina, including delivery of glucose and other nutrients. Here, we show that reductive carboxylation of ?-ketoglutarate, a type of metabolism that supports growth and survival of cancer cells, is a prominent feature of RPE cells. We show that extreme oxidative stress can overwhelm the reductive carboxylation pathway. However, we also found that the RPE can be protected from extreme oxidative stress by supplementation with an NAD+ precursor or ?-ketoglutarate. Twit Text FOAVip Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27911769 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27911769 #FOAvip English Wikipedia <ref>{{Cite pmid|27911769}}</ref> Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium #MMPMID27911769 Du J; Yanagida A; Knight K; Engel AL; Vo AH; Jankowski C; Sadilek M; Tran VTB; Manson MA; Ramakrishnan A; Hurley JB; Chao JR Proc Natl Acad Sci U S A 2016[Dec]; 113 (51): 14710-5 PMID27911769show ga In the vertebrate eye, a monolayer of cells, called the retinal pigment epithelium (RPE), is between the choroidal blood supply and the retina. The RPE provides metabolic support for the retina, including delivery of glucose and other nutrients. Here, we show that reductive carboxylation of ?-ketoglutarate, a type of metabolism that supports growth and survival of cancer cells, is a prominent feature of RPE cells. We show that extreme oxidative stress can overwhelm the reductive carboxylation pathway. However, we also found that the RPE can be protected from extreme oxidative stress by supplementation with an NAD+ precursor or ?-ketoglutarate. äReductive carboxylation is a major metabolic pathway in the retinal pi(epmc).pdf DeepDyve Pubget Overpricing