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10.1073/pnas.1610921114 http://scihub22266oqcxt.onion/10.1073/pnas.1610921114 C5187672!5187672!27930300     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (51): E8247-56 Nephropedia Template TP {{tp|p=27930300|t=2016. An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma |pdf=|usr=}}{{27930300}} gab.com Text An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27930300 #FOAvip Glioblastoma, the most common primary malignant brain tumor in adults, remains challenging despite multimodality therapy, necessitating the discovery of new therapies. Nicotinamide adenine dinucleotide (NAD+) plays a pivotal role in cancer cell metabolism, but how NAD+ impacts functional signaling events in glioblastoma is not well understood. We provide clinical evidence that high expression of NAMPT, the rate-limiting step in NAD+ biosynthesis, in glioblastoma tumors is associated with poor overall survival in patients, and demonstrate NAMPT and NAD+ are required for the maintenance of patient-derived glioblastoma stem-like cells (GSCs). Moreover, we delineate a NAD+-dependent transcriptional program that governs GSC self-renewal and dictates the radiation resistance of these cells. These findings identify potential new therapeutic avenues for the treatment of glioblastoma. Twit Text FOAVip An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27930300 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27930300 #FOAvip English Wikipedia <ref>{{Cite pmid|27930300}}</ref> An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma #MMPMID27930300 Gujar AD; Le S; Mao DD; Dadey DYA; Turski A; Sasaki Y; Aum D; Luo J; Dahiya S; Yuan L; Rich KM; Milbrandt J; Hallahan DE; Yano H; Tran DD; Kim AH Proc Natl Acad Sci U S A 2016[Dec]; 113 (51): E8247-56 PMID27930300show ga Glioblastoma, the most common primary malignant brain tumor in adults, remains challenging despite multimodality therapy, necessitating the discovery of new therapies. Nicotinamide adenine dinucleotide (NAD+) plays a pivotal role in cancer cell metabolism, but how NAD+ impacts functional signaling events in glioblastoma is not well understood. We provide clinical evidence that high expression of NAMPT, the rate-limiting step in NAD+ biosynthesis, in glioblastoma tumors is associated with poor overall survival in patients, and demonstrate NAMPT and NAD+ are required for the maintenance of patient-derived glioblastoma stem-like cells (GSCs). Moreover, we delineate a NAD+-dependent transcriptional program that governs GSC self-renewal and dictates the radiation resistance of these cells. These findings identify potential new therapeutic avenues for the treatment of glioblastoma. äAn NAD+-dependent transcriptional program governs self-renewal and rad(epmc).pdf DeepDyve Pubget Overpricing