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10.1093/hmg/ddw154 http://scihub22266oqcxt.onion/10.1093/hmg/ddw154 C5181595!5181595 !27288454     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27288454 &cmd=llinks): Failed to open stream: HTTP request failed! 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Genome-wide interrogation reveals hundreds of long intergenic noncoding RNAs that associate with cardiometabolic traits |pdf=|usr=}}{{27288454 }} gab.com Text Genome-wide interrogation reveals hundreds of long intergenic noncoding RNAs that associate with cardiometabolic traits JO: Hum Mol Genet http://www.kidney.de/pget.php?&tw=1&pmid=27288454 #FOAvip Long intergenic noncoding RNAs (lincRNAs) play important roles in disease, but the vast majority of these transcripts remain uncharacterized. We defined a set of 54 944 human lincRNAs by drawing on four publicly available lincRNA datasets, and annotated ?2.5 million single nucleotide polymorphisms (SNPs) from each of 15 cardiometabolic genome-wide association study datasets into these lincRNAs. We identified hundreds of lincRNAs with at least one trait-associated SNP: 898 SNPs in 343 unique lincRNAs at 5% false discovery rate, and 469 SNPs in 146 unique lincRNAs meeting Bonferroni-corrected P < 0.05. An additional 64 trait-associated lincRNAs were identified using a class-level testing strategy at Bonferroni-corrected P < 0.05. To better understand the genomic context and prioritize trait-associated lincRNAs, we examined the pattern of linkage disequilibrium between SNPs in the lincRNAs and SNPs that met genome-wide-significance in the region (±500 kb of lincRNAs). A subset of the lincRNA-trait association findings was replicated in independent Genome-wide association studies data from the Pakistan Risk of Myocardial Infarction Study study. For trait-associated lincRNAs, we also investigated synteny and conservation relative to mouse, expression patterns in five cardiometabolic-relevant tissues, and allele-specific expression in RNA sequencing data for adipose tissue and leukocytes. Finally, we revealed a functional role in human adipocytes for linc-NFE2L3-1, which is expressed in adipose and is associated with waist-hip ratio adjusted for BMI. This comprehensive profile of trait-associated lincRNAs provides novel insights into disease mechanism and serves as a launching point for interrogation of the biology of specific lincRNAs in cardiometabolic disease. Twit Text FOAVip Genome-wide interrogation reveals hundreds of long intergenic noncoding RNAs that associate with cardiometabolic traits ????Hum Mol Genet http://www.kidney.de/pget.php?&tw=1&pmid=27288454 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27288454 #FOAvip English Wikipedia <ref>{{Cite pmid|27288454 }}</ref> Genome-wide interrogation reveals hundreds of long intergenic noncoding RNAs that associate with cardiometabolic traits #MMPMID27288454 Ballantyne RL ; Zhang X ; Nuñez S ; Xue C ; Zhao W ; Reed E ; Salaheen D ; Foulkes AS ; Li M ; Reilly MP Hum Mol Genet 2016[Jul]; 25 (14 ): 3125-3141 PMID27288454 show ga Long intergenic noncoding RNAs (lincRNAs) play important roles in disease, but the vast majority of these transcripts remain uncharacterized. We defined a set of 54 944 human lincRNAs by drawing on four publicly available lincRNA datasets, and annotated ?2.5 million single nucleotide polymorphisms (SNPs) from each of 15 cardiometabolic genome-wide association study datasets into these lincRNAs. We identified hundreds of lincRNAs with at least one trait-associated SNP: 898 SNPs in 343 unique lincRNAs at 5% false discovery rate, and 469 SNPs in 146 unique lincRNAs meeting Bonferroni-corrected P < 0.05. An additional 64 trait-associated lincRNAs were identified using a class-level testing strategy at Bonferroni-corrected P < 0.05. To better understand the genomic context and prioritize trait-associated lincRNAs, we examined the pattern of linkage disequilibrium between SNPs in the lincRNAs and SNPs that met genome-wide-significance in the region (±500 kb of lincRNAs). A subset of the lincRNA-trait association findings was replicated in independent Genome-wide association studies data from the Pakistan Risk of Myocardial Infarction Study study. For trait-associated lincRNAs, we also investigated synteny and conservation relative to mouse, expression patterns in five cardiometabolic-relevant tissues, and allele-specific expression in RNA sequencing data for adipose tissue and leukocytes. Finally, we revealed a functional role in human adipocytes for linc-NFE2L3-1, which is expressed in adipose and is associated with waist-hip ratio adjusted for BMI. This comprehensive profile of trait-associated lincRNAs provides novel insights into disease mechanism and serves as a launching point for interrogation of the biology of specific lincRNAs in cardiometabolic disease. |*Genome, Human [MESH] |*Genome-Wide Association Study [MESH] |Adipocytes/metabolism [MESH] |Alleles [MESH] |Humans [MESH] |Linkage Disequilibrium [MESH] |Myocardial Infarction/*genetics/physiopathology [MESH] |Pakistan [MESH] |Polymorphism, Single Nucleotide [MESH] |RNA, Long Noncoding/*genetics [MESH] |Sequence Analysis, RNA [MESH]Genome-wide interrogation reveals hundreds of long intergenic noncodin(epmc).pdf DeepDyve Pubget Overpricing