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10.1097/TP.0000000000001341 http://scihub22266oqcxt.onion/10.1097/TP.0000000000001341 C5178883!5178883 !27472092     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27472092 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Transplantation 2017 ; 101 (3 ): 541-547 Nephropedia Template TP {{tp|p=27472092 |t=2017. Increased CD40 Ligation and Reduced BCR Signalling Leads to Higher IL-10 Production in B Cells From Tolerant Kidney Transplant Patients |pdf=|usr=}}{{27472092 }} gab.com Text Increased CD40 Ligation and Reduced BCR Signalling Leads to Higher IL-10 Production in B Cells From Tolerant Kidney Transplant Patients JO: Transplantation http://www.kidney.de/pget.php?&tw=1&pmid=27472092 #FOAvip BACKGROUND: An increased percentage of peripheral transitional B cells producing IL-10 has been observed in patients tolerant to kidney allografts. In healthy volunteers, the balance between the CD40 and B-cell receptor (BCR) signalling modulated IL-10 production by B cells, with stimulation via the BCR decreasing CD40-mediated IL-10 production. In this study, we evaluate whether in tolerant kidney transplant patients, the increased IL-10 production by B cells was due to an altered CD40 and/or BCR signalling. METHODS: B cells obtained from a new cohort of tolerant renal transplant recipients and those from age- and sex-matched healthy volunteers were activated via CD40 and BCR, either alone or in combination. RESULTS: In tolerant patients, we observed higher percentages of B cells producing IL-10 after CD40 ligation and higher expression of CD40L on activated T cells compared with healthy controls. Furthermore, B cells from tolerant recipients had reduced extracellular signal-regulated kinase signalling after BCR-mediated activation compared with healthy controls. In keeping with this, combining BCR signalling with CD40 ligation did not reduce IL-10 secretion as was observed in healthy control transitional B cells. CONCLUSIONS: Altogether, our data suggest that the altered response of B cells in tolerant recipients may contribute to long-term stable graft acceptance. Twit Text FOAVip Increased CD40 Ligation and Reduced BCR Signalling Leads to Higher IL-10 Production in B Cells From Tolerant Kidney Transplant Patients ????Transplantation http://www.kidney.de/pget.php?&tw=1&pmid=27472092 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27472092 #FOAvip English Wikipedia <ref>{{Cite pmid|27472092 }}</ref> Increased CD40 Ligation and Reduced BCR Signalling Leads to Higher IL-10 Production in B Cells From Tolerant Kidney Transplant Patients #MMPMID27472092 Nova-Lamperti E ; Chana P ; Mobillo P ; Runglall M ; Kamra Y ; McGregor R ; Lord GM ; Lechler RI ; Lombardi G ; Hernandez-Fuentes MP Transplantation 2017[Mar]; 101 (3 ): 541-547 PMID27472092 show ga BACKGROUND: An increased percentage of peripheral transitional B cells producing IL-10 has been observed in patients tolerant to kidney allografts. In healthy volunteers, the balance between the CD40 and B-cell receptor (BCR) signalling modulated IL-10 production by B cells, with stimulation via the BCR decreasing CD40-mediated IL-10 production. In this study, we evaluate whether in tolerant kidney transplant patients, the increased IL-10 production by B cells was due to an altered CD40 and/or BCR signalling. METHODS: B cells obtained from a new cohort of tolerant renal transplant recipients and those from age- and sex-matched healthy volunteers were activated via CD40 and BCR, either alone or in combination. RESULTS: In tolerant patients, we observed higher percentages of B cells producing IL-10 after CD40 ligation and higher expression of CD40L on activated T cells compared with healthy controls. Furthermore, B cells from tolerant recipients had reduced extracellular signal-regulated kinase signalling after BCR-mediated activation compared with healthy controls. In keeping with this, combining BCR signalling with CD40 ligation did not reduce IL-10 secretion as was observed in healthy control transitional B cells. CONCLUSIONS: Altogether, our data suggest that the altered response of B cells in tolerant recipients may contribute to long-term stable graft acceptance. |*Kidney Transplantation [MESH] |*Signal Transduction/drug effects [MESH] |*Transplantation Tolerance [MESH] |Adult [MESH] |Aged [MESH] |Allografts [MESH] |B-Lymphocytes/drug effects/immunology/*metabolism [MESH] |CD40 Antigens/immunology/*metabolism [MESH] |CD40 Ligand/genetics/immunology/*metabolism [MESH] |Case-Control Studies [MESH] |Cells, Cultured [MESH] |Extracellular Signal-Regulated MAP Kinases/metabolism [MESH] |Female [MESH] |Graft Survival [MESH] |Humans [MESH] |Interleukin-10/immunology/*metabolism [MESH] |Interleukin-2/pharmacology [MESH] |Lymphocyte Activation [MESH] |Male [MESH] |Middle Aged [MESH] |Receptors, Antigen, B-Cell/agonists/immunology/*metabolism [MESH] |T-Lymphocytes/immunology/metabolism [MESH] |Transfection [MESH] |Treatment Outcome [MESH] |Up-Regulation [MESH]Increased CD40 Ligation and Reduced BCR Signalling Leads to Higher IL-(epmc).pdf DeepDyve Pubget Overpricing