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2016 ; 15
(2
): 46-9
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Chest Pain Risk Stratification: A Comparison of the 2-Hour Accelerated Diagnostic
Protocol (ADAPT) and the HEART Pathway
#MMPMID27183253
Stopyra JP
; Miller CD
; Hiestand BC
; Lefebvre CW
; Nicks BA
; Cline DM
; Askew KL
; Riley RF
; Russell GB
; Burke GL
; Herrington D
; Hoekstra JW
; Mahler SA
Crit Pathw Cardiol
2016[Jun]; 15
(2
): 46-9
PMID27183253
show ga
BACKGROUND: The 2-hour accelerated diagnostic protocol (ADAPT) and the history
electrocardiogram age risk factors troponin (HEART) Pathway are decision aids
designed to identify Emergency Department (ED) patients with chest pain who are
safe for early discharge. Both have demonstrated high sensitivity (>99%) for
major adverse cardiac events (MACE) at 30 days and early discharge rates ?20%.
The objective of this study is to compare the sensitivity and early discharge
rates of the ADAPT and HEART Pathway decision aids in a cohort of ED patients
with acute chest pain. METHODS: A secondary analysis of participants enrolled and
randomized to the HEART Pathway arm of the HEART pathway randomized controlled
trial was conducted. Each patient was prospectively classified as low risk
(suitable for early discharge) or high risk by ADAPT and the HEART Pathway.
Sensitivity for MACE at 30 days and the number of patients identified as low-risk
were calculated for each decision aid. Decision aid performance was compared
using McNemar's test. RESULTS: MACE occurred in 8 of 141 (5.7%); there were no
deaths, 7 patients had myocardial infarction, and 1 patient had coronary
revascularization without myocardial infarction. ADAPT and the HEART pathway
identified all patients with MACE as high risk; sensitivity for MACE of 100% [95%
confidence interval (CI): 63-100%]. ADAPT identified 34 of 141 patients (24%; 95%
CI: 17-32%) as low-risk, whereas the Heart pathway identified 66 of 141 patients
(47%, 95% CI: 38-55%) as low risk (P < 0.001). CONCLUSIONS: Within a cohort of ED
patients with acute chest pain, ADAPT and the HEART pathway had high sensitivity
for MACE. The HEART pathway outperformed ADAPT by correctly identifying more
patients as low risk and safe for early discharge.