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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Exp+Biol+Med+(Maywood) 2017 ; 242 (2): 140-7 Nephropedia Template TP
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Epigenetic regulation of peroxiredoxins: Implications in the pathogenesis of cancer #MMPMID27633575
Ow SH; Chua PJ; Bay BH
Exp Biol Med (Maywood) 2017[Jan]; 242 (2): 140-7 PMID27633575show ga
Peroxiredoxin I to VI (PRX I?VI), a family of highly conserved antioxidants, has been implicated in numerous diseases. There have been reports that PRXs are expressed aberrantly in a variety of tumors, implying that they could play an important role in carcinogenesis. Epigenetic mechanisms such as DNA methylation, histone modifications, and microRNAs have been reported to modulate expression of PRXs. In addition, the use of epigenetic regulators, such as histone deacetylases, has been demonstrated to restore PRX to normal levels, indicating that the reversible nature of epigenetics can be exploited for future treatments.