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10.1083/jcb.201607039

http://scihub22266oqcxt.onion/10.1083/jcb.201607039
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C5166504!5166504!27864321
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suck abstract from ncbi


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pmid27864321      J+Cell+Biol 2016 ; 215 (6): 857-74
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  • Atg8 family LC3/GABARAP proteins are crucial for autophagosome?lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation #MMPMID27864321
  • Nguyen TN; Padman BS; Usher J; Oorschot V; Ramm G; Lazarou M
  • J Cell Biol 2016[Dec]; 215 (6): 857-74 PMID27864321show ga
  • Current autophagy models suggest that Atg8 family LC3/GABARAP proteins are essential mediators of autophagosome biogenesis. Nguyen et al. exploit CRISPR/Cas9-generated knockouts of the LC3 or GABARAP subfamilies, or both subfamilies, to show that Atg8s are dispensable for autophagosome biogenesis but essential for autophagosome?lysosome fusion.
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