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10.1083/jcb.201605089

http://scihub22266oqcxt.onion/10.1083/jcb.201605089
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C5166502!5166502!27932573
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suck abstract from ncbi


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pmid27932573      J+Cell+Biol 2016 ; 215 (6): 841-56
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  • Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation #MMPMID27932573
  • Nazio F; Carinci M; Valacca C; Bielli P; Strappazzon F; Antonioli M; Ciccosanti F; Rodolfo C; Campello S; Fimia GM; Sette C; Bonaldo P; Cecconi F
  • J Cell Biol 2016[Dec]; 215 (6): 841-56 PMID27932573show ga
  • ULK1 is a key kinase in autophagy initiation. Nazio et al. demonstrate that the E3 ubiquitin ligase NEDD4L targets ULK1 for degradation soon after autophagy induction, whereas a simultaneous ULK1 mRNA transcription is needed for priming subsequent rounds of autophagy.
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