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10.1083/jcb.201604112 http://scihub22266oqcxt.onion/10.1083/jcb.201604112 C5166498!5166498 !27956467     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27956467 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Biol 2016 ; 215 (6 ): 801-821 Nephropedia Template TP {{tp|p=27956467 |t=2016. LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining |pdf=|usr=}}{{27956467 }} gab.com Text LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27956467 #FOAvip The Caenorhabditis elegans SUN domain protein, UNC-84, functions in nuclear migration and anchorage in the soma. We discovered a novel role for UNC-84 in DNA damage repair and meiotic recombination. Loss of UNC-84 leads to defects in the loading and disassembly of the recombinase RAD-51. Similar to mutations in Fanconi anemia (FA) genes, unc-84 mutants and human cells depleted of Sun-1 are sensitive to DNA cross-linking agents, and sensitivity is rescued by the inactivation of nonhomologous end joining (NHEJ). UNC-84 also recruits FA nuclease FAN-1 to the nucleoplasm, suggesting that UNC-84 both alters the extent of repair by NHEJ and promotes the processing of cross-links by FAN-1. UNC-84 interacts with the KASH protein ZYG-12 for DNA damage repair. Furthermore, the microtubule network and interaction with the nucleoskeleton are important for repair, suggesting that a functional linker of nucleoskeleton and cytoskeleton (LINC) complex is required. We propose that LINC complexes serve a conserved role in DNA repair through both the inhibition of NHEJ and the promotion of homologous recombination at sites of chromosomal breaks. Twit Text FOAVip LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27956467 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27956467 #FOAvip English Wikipedia <ref>{{Cite pmid|27956467 }}</ref> LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining #MMPMID27956467 Lawrence KS ; Tapley EC ; Cruz VE ; Li Q ; Aung K ; Hart KC ; Schwartz TU ; Starr DA ; Engebrecht J J Cell Biol 2016[Dec]; 215 (6 ): 801-821 PMID27956467 show ga The Caenorhabditis elegans SUN domain protein, UNC-84, functions in nuclear migration and anchorage in the soma. We discovered a novel role for UNC-84 in DNA damage repair and meiotic recombination. Loss of UNC-84 leads to defects in the loading and disassembly of the recombinase RAD-51. Similar to mutations in Fanconi anemia (FA) genes, unc-84 mutants and human cells depleted of Sun-1 are sensitive to DNA cross-linking agents, and sensitivity is rescued by the inactivation of nonhomologous end joining (NHEJ). UNC-84 also recruits FA nuclease FAN-1 to the nucleoplasm, suggesting that UNC-84 both alters the extent of repair by NHEJ and promotes the processing of cross-links by FAN-1. UNC-84 interacts with the KASH protein ZYG-12 for DNA damage repair. Furthermore, the microtubule network and interaction with the nucleoskeleton are important for repair, suggesting that a functional linker of nucleoskeleton and cytoskeleton (LINC) complex is required. We propose that LINC complexes serve a conserved role in DNA repair through both the inhibition of NHEJ and the promotion of homologous recombination at sites of chromosomal breaks. |*DNA End-Joining Repair/drug effects/radiation effects [MESH] |*Homologous Recombination/drug effects/radiation effects [MESH] |Caenorhabditis elegans Proteins/*metabolism [MESH] |Cell Cycle Checkpoints/drug effects/radiation effects [MESH] |Cell Nucleus/drug effects/metabolism/radiation effects [MESH] |Cell Proliferation/drug effects/radiation effects [MESH] |Cisplatin/pharmacology [MESH] |Cross-Linking Reagents/metabolism [MESH] |DNA Damage [MESH] |Germ Cells/cytology/drug effects/metabolism/radiation effects [MESH] |Humans [MESH] |Hydroxyurea/pharmacology [MESH] |Meiosis/drug effects/radiation effects [MESH] |Membrane Proteins/metabolism [MESH] |Microtubule-Associated Proteins/metabolism [MESH] |Microtubules/drug effects/metabolism/radiation effects [MESH] |Models, Biological [MESH] |Multiprotein Complexes/*metabolism [MESH] |Nuclear Proteins/metabolism [MESH] |Polymerization/drug effects [MESH] |Protein Binding/drug effects/radiation effects [MESH] |Protein Transport/drug effects/radiation effects [MESH]LINC complexes promote homologous recombination in part through inhibi(epmc).pdf DeepDyve Pubget Overpricing