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Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Eur+J+Immunol 2016 ; 46 (7): 1704-14 Nephropedia Template TP
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Intravascular clearance of disseminating Cryptococcus neoformans in the brain can be improved by enhancing the recruitment of neutrophils #MMPMID27109176
Sun D; Zhang M; Liu G; Wu H; Li C; Zhou H; Zhang X; Shi M
Eur J Immunol 2016[Jul]; 46 (7): 1704-14 PMID27109176show ga
Extrapulmonary dissemination of Cryptococcus neoformans is one of the most critical steps in the development of meningoencephalitis. Here, we report that clearance of the disseminating C. neoformans occurs within the brain microvasculature. Interestingly, the efficiency of the intravascular clearance in the brain is not as great as that in the lung. Intravascular clearance is mainly mediated by neutrophils, and complement C5a receptor signaling is crucial via mediating neutrophil recruitment in the vasculature. C. neoformans-stimulated actin polymerization of neutrophils is critically involved in their recruitment to the lung, which is associated with the unique vascular structure detected in the lung. The relative lower efficiency of fungal clearance in the brain vasculature correlates with less efficient recruitment of neutrophils. Accordingly, intravascular clearance of C. neoformans in the brain could be remarkably improved by increasing the recruitment of neutrophils. We conclude that neutrophils have the ability to eliminate C. neoformans arrested in the vasculature. However, insufficient recruitment of neutrophils limited the optimal clearance of the organism in the brain. These results imply that a therapeutic strategy aimed at enhancing the accumulation of neutrophils could help prevent cryptococcal meningoencephalitis.