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10.1038/ni.3579 http://scihub22266oqcxt.onion/10.1038/ni.3579 C5164937!5164937 !27820809     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27820809 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Immunol 2017 ; 18 (1 ): 104-113 Nephropedia Template TP {{tp|p=27820809 |t=2017. Regulation of autoantibody activity by the IL-23-T(H)17 axis determines the onset of autoimmune disease |pdf=|usr=}}{{27820809 }} gab.com Text Regulation of autoantibody activity by the IL-23-T(H)17 axis determines the onset of autoimmune disease JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27820809 #FOAvip The checkpoints and mechanisms that contribute to autoantibody-driven disease are as yet incompletely understood. Here we identified the axis of interleukin 23 (IL-23) and the T(H)17 subset of helper T cells as a decisive factor that controlled the intrinsic inflammatory activity of autoantibodies and triggered the clinical onset of autoimmune arthritis. By instructing B cells in an IL-22- and IL-21-dependent manner, T(H)17 cells regulated the expression of ?-galactoside ?2,6-sialyltransferase 1 in newly differentiating antibody-producing cells and determined the glycosylation profile and activity of immunoglobulin G (IgG) produced by the plasma cells that subsequently emerged. Asymptomatic humans with rheumatoid arthritis (RA)-specific autoantibodies showed identical changes in the activity and glycosylation of autoreactive IgG antibodies before shifting to the inflammatory phase of RA; thus, our results identify an IL-23-T(H)17 cell-dependent pathway that controls autoantibody activity and unmasks a preexisting breach in immunotolerance. Twit Text FOAVip Regulation of autoantibody activity by the IL-23-T(H)17 axis determines the onset of autoimmune disease ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27820809 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27820809 #FOAvip English Wikipedia <ref>{{Cite pmid|27820809 }}</ref> Regulation of autoantibody activity by the IL-23-T(H)17 axis determines the onset of autoimmune disease #MMPMID27820809 Pfeifle R ; Rothe T ; Ipseiz N ; Scherer HU ; Culemann S ; Harre U ; Ackermann JA ; Seefried M ; Kleyer A ; Uderhardt S ; Haugg B ; Hueber AJ ; Daum P ; Heidkamp GF ; Ge C ; Böhm S ; Lux A ; Schuh W ; Magorivska I ; Nandakumar KS ; Lönnblom E ; Becker C ; Dudziak D ; Wuhrer M ; Rombouts Y ; Koeleman CA ; Toes R ; Winkler TH ; Holmdahl R ; Herrmann M ; Blüml S ; Nimmerjahn F ; Schett G ; Krönke G Nat Immunol 2017[Jan]; 18 (1 ): 104-113 PMID27820809 show ga The checkpoints and mechanisms that contribute to autoantibody-driven disease are as yet incompletely understood. Here we identified the axis of interleukin 23 (IL-23) and the T(H)17 subset of helper T cells as a decisive factor that controlled the intrinsic inflammatory activity of autoantibodies and triggered the clinical onset of autoimmune arthritis. By instructing B cells in an IL-22- and IL-21-dependent manner, T(H)17 cells regulated the expression of ?-galactoside ?2,6-sialyltransferase 1 in newly differentiating antibody-producing cells and determined the glycosylation profile and activity of immunoglobulin G (IgG) produced by the plasma cells that subsequently emerged. Asymptomatic humans with rheumatoid arthritis (RA)-specific autoantibodies showed identical changes in the activity and glycosylation of autoreactive IgG antibodies before shifting to the inflammatory phase of RA; thus, our results identify an IL-23-T(H)17 cell-dependent pathway that controls autoantibody activity and unmasks a preexisting breach in immunotolerance. |*Immune Tolerance [MESH] |Animals [MESH] |Arthritis, Rheumatoid/*immunology [MESH] |Autoantibodies/*metabolism [MESH] |B-Lymphocytes/*immunology [MESH] |Cell Differentiation [MESH] |Cells, Cultured [MESH] |Disease Models, Animal [MESH] |Glycosylation [MESH] |Humans [MESH] |Immunoglobulin G/*metabolism [MESH] |Interleukin-21 [MESH] |Interleukin-22 [MESH] |Interleukin-23/*metabolism [MESH] |Interleukins/metabolism [MESH] |Lymphocyte Activation [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Sialyltransferases/genetics/metabolism [MESH] |Signal Transduction [MESH] |Th17 Cells/*immunology [MESH]Regulation of autoantibody activity by the IL-23-T(H)17 axis determine(epmc).pdf DeepDyve Pubget Overpricing