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10.1038/ni.3632 http://scihub22266oqcxt.onion/10.1038/ni.3632 C5164931!5164931!27893700     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2017 ; 18 (1): 74-85 Nephropedia Template TP {{tp|p=27893700|t=2017. Trans-presentation of interleukin-6 by dendritic cells is required for priming pathogenic TH17 cells |pdf=|usr=}}{{27893700}} gab.com Text Trans-presentation of interleukin-6 by dendritic cells is required for priming pathogenic TH17 cells JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27893700 #FOAvip The cellular sources of interleukin-6 (IL-6) that are relevant for the differentiation of TH17 cells remain unclear. Here, we used a novel strategy of IL-6 conditional deletion of distinct IL-6-producing cell types to show that Sirp?+ dendritic cells (DC) were essential for the generation of pathogenic TH17 cells. During the process of cognate interaction, Sirp?+ DCs trans-presented IL-6 to T cells using their own IL-6R?. While ambient IL-6 was sufficient to suppress the induction of the transcription factor Foxp3 in T cells, IL-6 trans-presentation by DC-bound IL-6R? (here defined as IL-6 cluster signaling) was required to prevent premature induction of IFN-? in T cells and to generate pathogenic TH17 cells in vivo. These findings will guide therapeutic approaches for TH17-mediated autoimmune diseases. Twit Text FOAVip Trans-presentation of interleukin-6 by dendritic cells is required for priming pathogenic TH17 cells ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27893700 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27893700 #FOAvip English Wikipedia <ref>{{Cite pmid|27893700}}</ref> Trans-presentation of interleukin-6 by dendritic cells is required for priming pathogenic TH17 cells #MMPMID27893700 Heink S; Yogev N; Garbers C; Herwerth M; Aly L; Gasperi C; Husterer V; Croxford AL; Möller-Hackbarth K; Bartsch HS; Sotlar K; Krebs S; Regen T; Blum H; Hemmer B; Misgeld T; Wunderlich TF; Hidalgo J; Oukka M; Rose-John S; Schmidt-Supprian M; Waisman A; Korn T Nat Immunol 2017[Jan]; 18 (1): 74-85 PMID27893700show ga The cellular sources of interleukin-6 (IL-6) that are relevant for the differentiation of TH17 cells remain unclear. Here, we used a novel strategy of IL-6 conditional deletion of distinct IL-6-producing cell types to show that Sirp?+ dendritic cells (DC) were essential for the generation of pathogenic TH17 cells. During the process of cognate interaction, Sirp?+ DCs trans-presented IL-6 to T cells using their own IL-6R?. While ambient IL-6 was sufficient to suppress the induction of the transcription factor Foxp3 in T cells, IL-6 trans-presentation by DC-bound IL-6R? (here defined as IL-6 cluster signaling) was required to prevent premature induction of IFN-? in T cells and to generate pathogenic TH17 cells in vivo. These findings will guide therapeutic approaches for TH17-mediated autoimmune diseases. äTrans-presentation of interleukin-6 by dendritic cells is required for(epmc).pdf DeepDyve Pubget Overpricing