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10.1038/nature19325 http://scihub22266oqcxt.onion/10.1038/nature19325 C5161591!5161591!27602521     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2016 ; 537 (7620): 357-62 Nephropedia Template TP {{tp|p=27602521|t=2016. Locus coeruleus and dopaminergic consolidation of everyday memory |pdf=|usr=}}{{27602521}} gab.com Text Locus coeruleus and dopaminergic consolidation of everyday memory JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=27602521 #FOAvip The retention of episodic-like memory is enhanced, in humans and animals, when something novel happens shortly before or after encoding. Using an everyday memory task in mice, we sought the neurons mediating this dopamine-dependent novelty effect, previously thought to originate exclusively from the tyrosine hydroxylase-expressing (TH+) neurons in the ventral tegmental area (VTA). We report that neuronal firing in the locus coeruleus (LC) is especially sensitive to environmental novelty, LC-TH+ neurons project more profusely than VTA-TH+ neurons to the hippocampus, optogenetic activation of LC-TH+ neurons mimics the novelty effect, and this novelty-associated memory enhancement is unaffected by VTA inactivation. Surprisingly, two effects of LC-TH+ photoactivation are sensitive to hippocampal D1/D5 receptor blockade and resistant to adrenoceptors blockade ? memory enhancement and long lasting potentiation of synaptic transmission in CA1 ex vivo. Thus, LC-TH+ neurons can mediate post-encoding memory enhancement in a manner consistent with possible co-release of dopamine in hippocampus. Twit Text FOAVip Locus coeruleus and dopaminergic consolidation of everyday memory ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=27602521 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27602521 #FOAvip English Wikipedia <ref>{{Cite pmid|27602521}}</ref> Locus coeruleus and dopaminergic consolidation of everyday memory #MMPMID27602521 Takeuchi T; Duszkiewicz AJ; Sonneborn A; Spooner PA; Yamasaki M; Watanabe M; Smith CC; Fernández G; Deisseroth K; Greene RW; Morris RGM Nature 2016[Sep]; 537 (7620): 357-62 PMID27602521show ga The retention of episodic-like memory is enhanced, in humans and animals, when something novel happens shortly before or after encoding. Using an everyday memory task in mice, we sought the neurons mediating this dopamine-dependent novelty effect, previously thought to originate exclusively from the tyrosine hydroxylase-expressing (TH+) neurons in the ventral tegmental area (VTA). We report that neuronal firing in the locus coeruleus (LC) is especially sensitive to environmental novelty, LC-TH+ neurons project more profusely than VTA-TH+ neurons to the hippocampus, optogenetic activation of LC-TH+ neurons mimics the novelty effect, and this novelty-associated memory enhancement is unaffected by VTA inactivation. Surprisingly, two effects of LC-TH+ photoactivation are sensitive to hippocampal D1/D5 receptor blockade and resistant to adrenoceptors blockade ? memory enhancement and long lasting potentiation of synaptic transmission in CA1 ex vivo. Thus, LC-TH+ neurons can mediate post-encoding memory enhancement in a manner consistent with possible co-release of dopamine in hippocampus. äLocus coeruleus and dopaminergic consolidation of everyday memory (epmc).pdf DeepDyve Pubget Overpricing