Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/nature19347 http://scihub22266oqcxt.onion/10.1038/nature19347 C5161587!5161587!27580028     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2016 ; 537 (7620): 422-6 Nephropedia Template TP {{tp|p=27580028|t=2016. A PGC1?-mediated transcriptional axis suppresses melanoma metastasis |pdf=|usr=}}{{27580028}} gab.com Text A PGC1 -mediated transcriptional axis suppresses melanoma metastasis JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=27580028 #FOAvip Melanoma is the deadliest form of commonly encountered skin cancers because of its rapid progression towards metastasis1,2. Although metabolic reprogramming is tightly associated with tumor progression, whether metabolic regulatory circuits affect metastatic processes is poorly understood. PGC1? is a transcriptional coactivator that promotes mitochondrial biogenesis, protects against oxidative stress3, and reprograms melanoma metabolism to influence drug sensitivity and survival4,5. Here, we provide data to indicate that PGC1? suppresses melanoma metastasis, acting through a pathway distinct from its bioenergetic functions. Elevated PGC1? expression inversely correlates with vertical growth in human melanomas. PGC1? silencing makes nonmetastatic melanoma cells highly invasive and conversely, PGC1? reconstitution suppresses metastasis. Within populations of melanoma cells, there is a marked heterogeneity in PGC1? levels, which predicts their inherent high or low metastatic capacity. Mechanistically, PGC1? directly increases transcription of ID2, which in turn binds to and inactivates the transcription factor TCF4. Inactive TCF4 causes downregulation of metastasis-related genes including integrins that are known to influence invasion and metastasis6?8. Inhibition of BRAFV600E using vemurafenib9, independently of its cytostatic effects, suppresses metastasis by acting on the PGC1?-ID2-TCF4-integrin axis. Taken together, our findings reveal that PGC1? maintains mitochondrial energetic metabolism and suppresses metastasis through direct regulation of parallel acting transcriptional programs. Consequently, components of these circuits define new therapeutic opportunities that may help curb melanoma metastasis. Twit Text FOAVip A PGC1 -mediated transcriptional axis suppresses melanoma metastasis ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=27580028 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27580028 #FOAvip English Wikipedia <ref>{{Cite pmid|27580028}}</ref> A PGC1?-mediated transcriptional axis suppresses melanoma metastasis #MMPMID27580028 Luo C; Lim JH; Lee Y; Granter SR; Thomas A; Vazquez F; Widlund HR; Puigserver P Nature 2016[Sep]; 537 (7620): 422-6 PMID27580028show ga Melanoma is the deadliest form of commonly encountered skin cancers because of its rapid progression towards metastasis1,2. Although metabolic reprogramming is tightly associated with tumor progression, whether metabolic regulatory circuits affect metastatic processes is poorly understood. PGC1? is a transcriptional coactivator that promotes mitochondrial biogenesis, protects against oxidative stress3, and reprograms melanoma metabolism to influence drug sensitivity and survival4,5. Here, we provide data to indicate that PGC1? suppresses melanoma metastasis, acting through a pathway distinct from its bioenergetic functions. Elevated PGC1? expression inversely correlates with vertical growth in human melanomas. PGC1? silencing makes nonmetastatic melanoma cells highly invasive and conversely, PGC1? reconstitution suppresses metastasis. Within populations of melanoma cells, there is a marked heterogeneity in PGC1? levels, which predicts their inherent high or low metastatic capacity. Mechanistically, PGC1? directly increases transcription of ID2, which in turn binds to and inactivates the transcription factor TCF4. Inactive TCF4 causes downregulation of metastasis-related genes including integrins that are known to influence invasion and metastasis6?8. Inhibition of BRAFV600E using vemurafenib9, independently of its cytostatic effects, suppresses metastasis by acting on the PGC1?-ID2-TCF4-integrin axis. Taken together, our findings reveal that PGC1? maintains mitochondrial energetic metabolism and suppresses metastasis through direct regulation of parallel acting transcriptional programs. Consequently, components of these circuits define new therapeutic opportunities that may help curb melanoma metastasis. äA PGC1?-mediated transcriptional axis suppresses melanoma metastasis (epmc).pdf DeepDyve Pubget Overpricing