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10.1182/blood-2016-02-702761

http://scihub22266oqcxt.onion/10.1182/blood-2016-02-702761
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C5161010!5161010!27252232
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suck abstract from ncbi

pmid27252232      Blood 2016 ; 128 (3): 331-6
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  • Idelalisib in the management of lymphoma #MMPMID27252232
  • Cheah CY; Fowler NH
  • Blood 2016[Jul]; 128 (3): 331-6 PMID27252232show ga
  • Inhibition of the phosphatidylinositol-3-kinase (PI3K) pathway as an anticancer therapeutic strategy was realized with the approval of the orally bioavailable small molecule PI3K? inhibitor idelalisib. In this focused review, we highlight the rationale for targeting the pathway in lymphomas, provide a brief summary of the preclinical data, and describe the clinical experience with this agent in patients with lymphoma. We describe some of the idiosyncratic toxicities of this agent, some of the mechanisms of resistance, and some of the ongoing combination strategies.
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