The Renal Arterial Resistance Index Predicts Worsening Renal Function in Chronic
Heart Failure Patients
#MMPMID27994601
Iacoviello M
; Monitillo F
; Leone M
; Citarelli G
; Doronzo A
; Antoncecchi V
; Puzzovivo A
; Rizzo C
; Lattarulo MS
; Massari F
; Caldarola P
; Ciccone MM
Cardiorenal Med
2016[Nov]; 7
(1
): 42-49
PMID27994601
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BACKGROUND/AIM: The renal arterial resistance index (RRI) is a Doppler measure,
which reflects abnormalities in the renal blood flow. The aim of this study was
to verify the value of RRI as a predictor of worsening renal function (WRF) in a
group of chronic heart failure (CHF) outpatients. METHODS: We enrolled 266
patients in stable clinical conditions and on conventional therapy. Peak systolic
velocity and end diastolic velocity of a segmental renal artery were obtained by
pulsed Doppler flow, and RRI was calculated. Creatinine serum levels were
evaluated at baseline and at 1 year, and the changes were used to assess WRF
occurrence. RESULTS: During follow-up, 34 (13%) patients showed WRF. RRI was
associated with WRF at univariate (OR: 1.13; 95% CI: 1.07-1.20) as well as at a
forward stepwise multivariate logistic regression analysis (OR: 1.09; 95% CI:
1.03-1.16; p = 0.005) including the other univariate predictors. CONCLUSIONS:
Quantification of arterial renal perfusion provides a new parameter that
independently predicts the WRF in CHF outpatients. Its possible role in current
clinical practice to better define the risk of cardiorenal syndrome progression
is strengthened.
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