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10.1101/gad.290593.116 http://scihub22266oqcxt.onion/10.1101/gad.290593.116 C5159663!5159663 !27913604     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27913604 &cmd=llinks): Failed to open stream: HTTP request failed! 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Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program |pdf=|usr=}}{{27913604 }} gab.com Text Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program JO: Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=27913604 #FOAvip In general, cell fate is determined primarily by transcription factors, followed by epigenetic mechanisms fixing the status. While the importance of transcription factors controlling cell fate has been well characterized, epigenetic regulation of cell fate maintenance remains to be elucidated. Here we provide an obvious fate conversion case, in which the inactivation of polycomb-medicated epigenetic regulation results in conversion of T-lineage progenitors to the B-cell fate. In T-cell-specific Ring1A/B-deficient mice, T-cell development was severely blocked at an immature stage. We found that these developmentally arrested T-cell precursors gave rise to functional B cells upon transfer to immunodeficient mice. We further demonstrated that the arrest was almost completely canceled by additional deletion of Pax5 These results indicate that the maintenance of T-cell fate critically requires epigenetic suppression of the B-lineage gene program. Twit Text FOAVip Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program ????Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=27913604 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27913604 #FOAvip English Wikipedia <ref>{{Cite pmid|27913604 }}</ref> Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program #MMPMID27913604 Ikawa T ; Masuda K ; Endo TA ; Endo M ; Isono K ; Koseki Y ; Nakagawa R ; Kometani K ; Takano J ; Agata Y ; Katsura Y ; Kurosaki T ; Vidal M ; Koseki H ; Kawamoto H Genes Dev 2016[Nov]; 30 (22 ): 2475-2485 PMID27913604 show ga In general, cell fate is determined primarily by transcription factors, followed by epigenetic mechanisms fixing the status. While the importance of transcription factors controlling cell fate has been well characterized, epigenetic regulation of cell fate maintenance remains to be elucidated. Here we provide an obvious fate conversion case, in which the inactivation of polycomb-medicated epigenetic regulation results in conversion of T-lineage progenitors to the B-cell fate. In T-cell-specific Ring1A/B-deficient mice, T-cell development was severely blocked at an immature stage. We found that these developmentally arrested T-cell precursors gave rise to functional B cells upon transfer to immunodeficient mice. We further demonstrated that the arrest was almost completely canceled by additional deletion of Pax5 These results indicate that the maintenance of T-cell fate critically requires epigenetic suppression of the B-lineage gene program. |*Gene Silencing [MESH] |Animals [MESH] |B-Lymphocytes/*cytology [MESH] |Cell Lineage [MESH] |Cell Transformation, Neoplastic/*genetics [MESH] |Epigenesis, Genetic/*genetics [MESH] |Gene Deletion [MESH] |Gene Expression Regulation, Developmental [MESH] |Immunoglobulin Heavy Chains/genetics [MESH] |Mice, Inbred C57BL [MESH] |PAX5 Transcription Factor/genetics/metabolism [MESH] |Polycomb Repressive Complex 1/genetics [MESH] |Polycomb-Group Proteins/*metabolism [MESH] |Promoter Regions, Genetic/genetics [MESH] |T-Lymphocytes/*cytology [MESH]Conversion of T cells to B cells by inactivation of polycomb-mediated (epmc).pdf DeepDyve Pubget Overpricing